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1U8A

Crystal Structure of Mycobacterium Tuberculosis Shikimate Kinase in Complex with Shikimate and ADP at 2.15 Angstrom Resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004765molecular_functionshikimate kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008652biological_processamino acid biosynthetic process
A0009073biological_processaromatic amino acid family biosynthetic process
A0009423biological_processchorismate biosynthetic process
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0019632biological_processshikimate metabolic process
A0019752biological_processcarboxylic acid metabolic process
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 190
ChainResidue
AARG66
AARG160

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 191
ChainResidue
AGLY29
AHIS72
AGLY74

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 192
ChainResidue
AARG66
AALA90
AARG109
AHOH264

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ADP A 180
ChainResidue
ALEU10
AGLY12
ASER13
AGLY14
ALYS15
ASER16
ATHR17
AARG110
AARG117
AARG153
AASN154
APRO155
AHOH194
AHOH198
AHOH199
AHOH209
AHOH260
AHOH260
AHOH274
AHOH291

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE SKM A 181
ChainResidue
APRO11
AASP34
AARG58
AGLY79
AGLY80
AGLY81
APRO118
ALEU119
AARG136
AHOH193
AHOH194
AHOH195
AHOH197

Functional Information from PROSITE/UniProt
site_idPS01128
Number of Residues26
DetailsSHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV
ChainResidueDetails
AARG58-VAL83

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AGLY12
ASER16
AASP34
AARG58
AGLY80
AARG117
AARG136
AARG153

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PDB entries from 2024-10-30

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