1U2Q
Crystal structure of Mycobacterium tuberculosis Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) at 2.5A resolution with glycerol in the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004438 | molecular_function | phosphatidylinositol-3-phosphate phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0033668 | biological_process | symbiont-mediated suppression of host apoptosis |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0052067 | biological_process | symbiont-mediated perturbation of host phagocytosis |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | CYS11 |
| A | ASN14 |
| A | ILE15 |
| A | CYS16 |
| A | GOL165 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 165 |
| Chain | Residue |
| A | HOH202 |
| A | GLY13 |
| A | ARG32 |
| A | HIS49 |
| A | CL164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835 |
| Chain | Residue | Details |
| A | CYS11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835 |
| Chain | Residue | Details |
| A | ARG17 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835 |
| Chain | Residue | Details |
| A | ASP126 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PknA => ECO:0000269|PubMed:25535696 |
| Chain | Residue | Details |
| A | THR45 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:20830431, ECO:0000269|PubMed:23102706 |
| Chain | Residue | Details |
| A | CYS53 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19366344, ECO:0000269|PubMed:22888002, ECO:0000269|PubMed:25535696 |
| Chain | Residue | Details |
| A | TYR128 | |
| A | TYR129 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| A | ARG17 | |
| A | ASP126 | |
| A | CYS11 | |
| A | CYS16 |
