1U2Q
Crystal structure of Mycobacterium tuberculosis Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) at 2.5A resolution with glycerol in the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004438 | molecular_function | phosphatidylinositol-3-phosphate phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0033668 | biological_process | symbiont-mediated suppression of host apoptosis |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0052067 | biological_process | symbiont-mediated perturbation of host phagocytosis |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0141159 | biological_process | symbiont-mediated suppression of host phagosome acidification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | CYS11 |
| A | ASN14 |
| A | ILE15 |
| A | CYS16 |
| A | GOL165 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 165 |
| Chain | Residue |
| A | HOH202 |
| A | GLY13 |
| A | ARG32 |
| A | HIS49 |
| A | CL164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"UIM-like region","evidences":[{"source":"PubMed","id":"36227980","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15743966","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17975835","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15743966","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17975835","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15743966","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17975835","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PknA","evidences":[{"source":"PubMed","id":"25535696","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"20830431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23102706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19366344","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22888002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25535696","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| A | ARG17 | |
| A | ASP126 | |
| A | CYS11 | |
| A | CYS16 |
