1U2O

Crystal Structure Of The N-Domain Of Grp94 Lacking The Charged Domain In Complex With Neca

Replaces:  1QYH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NEC A 1001

Chain	Residue
A	ALA111
A	HOH2015
A	HOH2039
A	HOH2059
A	HOH2065
A	HOH2079
A	ASP149
A	MET154
A	ASN162
A	GLY196
A	VAL197
A	TYR200
A	HOH2004
A	HOH2009

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NEC B 1002

Chain	Residue
B	ASN107
B	ALA111
B	ASP149
B	MET154
B	ASN162
B	LEU163
B	GLY196
B	VAL197
B	TYR200
B	HOH2012
B	HOH2013
B	HOH2014
B	HOH2069
B	HOH2138
B	HOH2141

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 A 2001

Chain	Residue
A	THR212
A	ARG237
A	THR246
A	THR248
A	PG42002
A	HOH2085
A	HOH2134

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 2002

Chain	Residue
A	LYS137
A	THR148
A	TRP282
A	PG42001
A	HOH2046
A	HOH2134

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1PE B 2006

Chain	Residue
A	ASN83
A	MET86
A	LYS87
A	SER227
B	ASN83
B	LYS87
B	ILE90
B	SER227
B	HOH2124

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 B 2008

Chain	Residue
B	THR212
B	ARG237
B	THR240
B	THR248
B	PG42009
B	HOH2016
B	HOH2072
B	HOH2112

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 2009

Chain	Residue
B	LYS137
B	THR148
B	TRP282
B	PG42008

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 2011

Chain	Residue
B	GLY128
B	ASN129
B	ASN239
B	GLY242

---

Functional Information from PROSITE/UniProt

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YkNKEIFLRE

Chain	Residue	Details
A	TYR94-GLU103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN107
B	ASN107

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASP149
B	ASP149
B	PHE199
A	PHE199

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN162
B	ASN162

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P14625

Chain	Residue	Details
A	LYS168
B	LYS168

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q66HD0

Chain	Residue	Details
A	SER172
B	SER172

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000255

Chain	Residue	Details
A	GLY325
B	GLY325

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P14625, ECO:0000255

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN107
A	ASN217
B	ASN107
B	ASN217

---