1U1Z
The Structure of (3R)-hydroxyacyl-ACP dehydratase (FabZ)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016836 | molecular_function | hydro-lyase activity |
| A | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016836 | molecular_function | hydro-lyase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016836 | molecular_function | hydro-lyase activity |
| C | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016836 | molecular_function | hydro-lyase activity |
| D | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0009245 | biological_process | lipid A biosynthetic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016836 | molecular_function | hydro-lyase activity |
| E | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0009245 | biological_process | lipid A biosynthetic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016836 | molecular_function | hydro-lyase activity |
| F | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 500 |
| Chain | Residue |
| D | ARG34 |
| D | HOH525 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 501 |
| Chain | Residue |
| B | LYS117 |
| B | ARG118 |
| B | SER119 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 502 |
| Chain | Residue |
| B | LYS117 |
| B | ARG118 |
| D | GLY84 |
| D | LYS145 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 503 |
| Chain | Residue |
| D | ARG118 |
| D | SER119 |
| D | ARG144 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 504 |
| Chain | Residue |
| B | ASP83 |
| B | LYS145 |
| D | LYS117 |
| D | ARG118 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00406 |
| Chain | Residue | Details |
| A | HIS49 | |
| B | HIS49 | |
| C | HIS49 | |
| D | HIS49 | |
| E | HIS49 | |
| F | HIS49 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| F | GLU63 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| A | GLU63 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| B | GLU63 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| C | GLU63 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| D | GLU63 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mka |
| Chain | Residue | Details |
| E | GLU63 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| A | HIS49 | proton acceptor, proton donor |
| A | ILE55 | electrostatic stabiliser |
| A | GLY58 | electrostatic stabiliser |
| A | VAL59 | electrostatic stabiliser, ground state destabiliser |
| A | GLU63 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| B | HIS49 | proton acceptor, proton donor |
| B | ILE55 | electrostatic stabiliser |
| B | GLY58 | electrostatic stabiliser |
| B | VAL59 | electrostatic stabiliser, ground state destabiliser |
| B | GLU63 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| C | HIS49 | proton acceptor, proton donor |
| C | ILE55 | electrostatic stabiliser |
| C | GLY58 | electrostatic stabiliser |
| C | VAL59 | electrostatic stabiliser, ground state destabiliser |
| C | GLU63 | proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| D | HIS49 | proton acceptor, proton donor |
| D | ILE55 | electrostatic stabiliser |
| D | GLY58 | electrostatic stabiliser |
| D | VAL59 | electrostatic stabiliser, ground state destabiliser |
| D | GLU63 | proton acceptor, proton donor |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| E | HIS49 | proton acceptor, proton donor |
| E | ILE55 | electrostatic stabiliser |
| E | GLY58 | electrostatic stabiliser |
| E | VAL59 | electrostatic stabiliser, ground state destabiliser |
| E | GLU63 | proton acceptor, proton donor |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 947 |
| Chain | Residue | Details |
| F | HIS49 | proton acceptor, proton donor |
| F | ILE55 | electrostatic stabiliser |
| F | GLY58 | electrostatic stabiliser |
| F | VAL59 | electrostatic stabiliser, ground state destabiliser |
| F | GLU63 | proton acceptor, proton donor |
