1U1G
Structure of E. coli uridine phosphorylase complexed to 5-(m-(benzyloxy)benzyl)barbituric acid (BBBA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046050 | biological_process | UMP catabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046050 | biological_process | UMP catabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006218 | biological_process | uridine catabolic process |
| C | 0006974 | biological_process | DNA damage response |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0044206 | biological_process | UMP salvage |
| C | 0046050 | biological_process | UMP catabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006218 | biological_process | uridine catabolic process |
| D | 0006974 | biological_process | DNA damage response |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0044206 | biological_process | UMP salvage |
| D | 0046050 | biological_process | UMP catabolic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006218 | biological_process | uridine catabolic process |
| E | 0006974 | biological_process | DNA damage response |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0030955 | molecular_function | potassium ion binding |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0044206 | biological_process | UMP salvage |
| E | 0046050 | biological_process | UMP catabolic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006218 | biological_process | uridine catabolic process |
| F | 0006974 | biological_process | DNA damage response |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0030955 | molecular_function | potassium ion binding |
| F | 0032991 | cellular_component | protein-containing complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0044206 | biological_process | UMP salvage |
| F | 0046050 | biological_process | UMP catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 1001 |
| Chain | Residue |
| C | GLU49 |
| C | ILE69 |
| C | SER73 |
| D | GLU49 |
| D | ILE69 |
| D | SER73 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1002 |
| Chain | Residue |
| B | GLU49 |
| B | ILE69 |
| B | SER73 |
| A | GLU49 |
| A | ILE69 |
| A | SER73 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 1003 |
| Chain | Residue |
| E | GLU49 |
| E | ILE69 |
| E | SER73 |
| F | GLU49 |
| F | ILE69 |
| F | SER73 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BBB A 3300 |
| Chain | Residue |
| A | THR94 |
| A | THR95 |
| A | GLY96 |
| A | PHE162 |
| A | GLN166 |
| A | ARG168 |
| A | GLU196 |
| A | MET197 |
| A | HOH3305 |
| B | PHE7 |
| B | HIS8 |
| B | ARG48 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BBB B 4300 |
| Chain | Residue |
| A | PHE7 |
| A | HIS8 |
| A | ARG48 |
| B | THR94 |
| B | PHE162 |
| B | GLN166 |
| B | ARG168 |
| B | TYR195 |
| B | GLU196 |
| B | MET197 |
| B | GLU227 |
| B | HOH4376 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BBB C 5300 |
| Chain | Residue |
| C | THR94 |
| C | THR95 |
| C | GLY96 |
| C | GLN166 |
| C | ARG168 |
| C | TYR195 |
| C | GLU196 |
| C | MET197 |
| C | MET234 |
| C | HOH5320 |
| C | HOH5392 |
| D | PHE7 |
| D | HIS8 |
| D | ARG48 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BBB D 6300 |
| Chain | Residue |
| C | PHE7 |
| C | HIS8 |
| D | THR94 |
| D | THR95 |
| D | GLY96 |
| D | GLN166 |
| D | ARG168 |
| D | TYR195 |
| D | GLU196 |
| D | MET197 |
| D | GLU227 |
| D | HOH6321 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BBB E 7300 |
| Chain | Residue |
| E | THR94 |
| E | THR95 |
| E | GLY96 |
| E | PHE162 |
| E | GLN166 |
| E | ARG168 |
| E | TYR195 |
| E | GLU196 |
| E | MET197 |
| E | VAL221 |
| E | HOH7314 |
| F | PHE7 |
| F | HIS8 |
| F | ARG48 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BBB F 8300 |
| Chain | Residue |
| E | PHE7 |
| E | HIS8 |
| E | ARG48 |
| F | THR94 |
| F | PHE162 |
| F | GLN166 |
| F | ARG168 |
| F | TYR195 |
| F | GLU196 |
| F | HOH8307 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER66-LEU81 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| A | GLU80 | |
| A | HIS8 | |
| A | ARG223 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| B | GLU80 | |
| B | HIS8 | |
| B | ARG223 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| C | GLU80 | |
| C | HIS8 | |
| C | ARG223 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| D | GLU80 | |
| D | HIS8 | |
| D | ARG223 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| E | GLU80 | |
| E | HIS8 | |
| E | ARG223 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| F | GLU80 | |
| F | HIS8 | |
| F | ARG223 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| A | HIS8 | proton acceptor, proton donor |
| A | GLU80 | electrostatic stabiliser, polar interaction |
| A | ARG168 | proton acceptor, proton donor |
| A | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| B | HIS8 | proton acceptor, proton donor |
| B | GLU80 | electrostatic stabiliser, polar interaction |
| B | ARG168 | proton acceptor, proton donor |
| B | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| C | HIS8 | proton acceptor, proton donor |
| C | GLU80 | electrostatic stabiliser, polar interaction |
| C | ARG168 | proton acceptor, proton donor |
| C | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| D | HIS8 | proton acceptor, proton donor |
| D | GLU80 | electrostatic stabiliser, polar interaction |
| D | ARG168 | proton acceptor, proton donor |
| D | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| E | HIS8 | proton acceptor, proton donor |
| E | GLU80 | electrostatic stabiliser, polar interaction |
| E | ARG168 | proton acceptor, proton donor |
| E | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| F | HIS8 | proton acceptor, proton donor |
| F | GLU80 | electrostatic stabiliser, polar interaction |
| F | ARG168 | proton acceptor, proton donor |
| F | ARG223 | electrostatic stabiliser, polar interaction |
