Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1TZN

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0005576	cellular_component	extracellular region
C	0051260	biological_process	protein homooligomerization
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0005576	cellular_component	extracellular region
F	0051260	biological_process	protein homooligomerization
G	0005576	cellular_component	extracellular region
G	0051260	biological_process	protein homooligomerization
H	0005576	cellular_component	extracellular region
H	0051260	biological_process	protein homooligomerization
I	0005576	cellular_component	extracellular region
I	0051260	biological_process	protein homooligomerization
J	0005576	cellular_component	extracellular region
J	0051260	biological_process	protein homooligomerization
K	0005576	cellular_component	extracellular region
K	0051260	biological_process	protein homooligomerization
L	0005576	cellular_component	extracellular region
L	0051260	biological_process	protein homooligomerization
M	0005576	cellular_component	extracellular region
M	0051260	biological_process	protein homooligomerization
O	0005576	cellular_component	extracellular region
O	0051260	biological_process	protein homooligomerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 736

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188
A	CA737

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 737

Chain	Residue
A	SER222
A	LYS225
A	ASP235
A	CA736
A	ASP179
A	ASP181
A	GLU188

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 738

Chain	Residue
A	ASP683
a	SER1052
a	SER1054
a	THR1118
a	ASP1148

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 736

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188
B	CA737

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 737

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER222
B	LYS225
B	ASP235
B	CA736

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 738

Chain	Residue
B	ASP683
b	SER1052
b	SER1054
b	THR1118
b	ASP1148

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 736

Chain	Residue
C	ASP177
C	ASP179
C	ASP181
C	ILE183
C	GLU188
C	CA737

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 737

Chain	Residue
C	ASP179
C	ASP181
C	GLU188
C	SER222
C	LYS225
C	ASP235
C	CA736

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 738

Chain	Residue
C	ASP683
c	SER1052
c	SER1054
c	THR1118
c	ASP1148

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 736

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	GLU188
D	CA737

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 737

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235
D	CA736

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 738

Chain	Residue
D	ASP683
d	SER1052
d	SER1054
d	THR1118
d	ASP1148

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 736

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	GLU188
E	CA737

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 737

Chain	Residue
E	ASP179
E	ASP181
E	GLU188
E	SER222
E	LYS225
E	ASP235
E	CA736

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 738

Chain	Residue
E	ASP683
e	SER1052
e	SER1054
e	THR1118
e	ASP1148

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 736

Chain	Residue
F	ASP177
F	ASP179
F	ASP181
F	ILE183
F	GLU188
F	CA737

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA F 737

Chain	Residue
F	SER222
F	LYS225
F	ASP235
F	CA736
F	ASP179
F	ASP181
F	GLU188

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 738

Chain	Residue
F	ASP683
f	SER1052
f	SER1054
f	THR1118
f	ASP1148

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 736

Chain	Residue
G	ASP177
G	ASP179
G	ASP181
G	ILE183
G	GLU188
G	CA737

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA G 737

Chain	Residue
G	ASP179
G	ASP181
G	GLU188
G	SER222
G	LYS225
G	ASP235
G	CA736

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 738

Chain	Residue
G	ASP683
g	SER1052
g	SER1054
g	THR1118
g	ASP1148

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 736

Chain	Residue
H	ASP177
H	ASP179
H	ASP181
H	ILE183
H	GLU188
H	CA737

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA H 737

Chain	Residue
H	ASP179
H	ASP181
H	GLU188
H	SER222
H	LYS225
H	ASP235
H	CA736

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG H 738

Chain	Residue
H	ASP683
h	SER1052
h	SER1054
h	THR1118
h	ASP1148

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 736

Chain	Residue
I	ASP177
I	ASP179
I	ASP181
I	ILE183
I	GLU188
I	CA737

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA I 737

Chain	Residue
I	ASP179
I	ASP181
I	GLU188
I	SER222
I	LYS225
I	ASP235
I	CA736

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG I 738

Chain	Residue
I	ASP683
i	SER1052
i	SER1054
i	THR1118
i	ASP1148

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 736

Chain	Residue
J	ASP177
J	ASP179
J	ASP181
J	ILE183
J	GLU188
J	CA737

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA J 737

Chain	Residue
J	ASP179
J	ASP181
J	GLU188
J	SER222
J	LYS225
J	ASP235
J	CA736

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 738

Chain	Residue
J	ASP683
j	SER1052
j	SER1054
j	THR1118
j	ASP1148

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 736

Chain	Residue
K	ASP177
K	ASP179
K	ASP181
K	ILE183
K	GLU188
K	CA737

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA K 737

Chain	Residue
K	ASP179
K	ASP181
K	GLU188
K	SER222
K	LYS225
K	ASP235
K	CA736

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG K 738

Chain	Residue
K	ASP683
k	SER1052
k	SER1054
k	THR1118
k	ASP1148

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 736

Chain	Residue
L	ASP177
L	ASP179
L	ASP181
L	ILE183
L	GLU188
L	CA737

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA L 737

Chain	Residue
L	ASP179
L	ASP181
L	GLU188
L	SER222
L	LYS225
L	ASP235
L	CA736

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG L 738

Chain	Residue
L	ASP683
l	SER1052
l	SER1054
l	THR1118
l	ASP1148

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 736

Chain	Residue
M	ASP177
M	ASP179
M	ASP181
M	ILE183
M	GLU188
M	CA737

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA M 737

Chain	Residue
M	ASP179
M	ASP181
M	GLU188
M	SER222
M	LYS225
M	ASP235
M	CA736

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG M 738

Chain	Residue
M	ASP683
m	SER1052
m	SER1054
m	THR1118
m	ASP1148

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA O 736

Chain	Residue
O	ASP177
O	ASP179
O	ASP181
O	ILE183
O	GLU188
O	CA737

site_id	EC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA O 737

Chain	Residue
O	ASP179
O	ASP181
O	GLU188
O	SER222
O	LYS225
O	ASP235
O	CA736

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG O 738

Chain	Residue
O	ASP683
o	SER1052
o	SER1054
o	THR1118
o	ASP1148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	112
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1498
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1946
Details	Region: {"description":"Domain 4, binding to the receptor","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	56
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	14
Details	Site: {"description":"Cleavage; by chymotrypsin; required for translocation of LF and EF","evidences":[{"source":"PubMed","id":"7961869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	14
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2366
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15079089","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	14
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)