Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1TZL

Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0050233	molecular_function	pyranose oxidase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0050233	molecular_function	pyranose oxidase activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0050233	molecular_function	pyranose oxidase activity
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0050233	molecular_function	pyranose oxidase activity
D	0050660	molecular_function	flavin adenine dinucleotide binding
E	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
E	0050233	molecular_function	pyranose oxidase activity
E	0050660	molecular_function	flavin adenine dinucleotide binding
F	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
F	0050233	molecular_function	pyranose oxidase activity
F	0050660	molecular_function	flavin adenine dinucleotide binding
G	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
G	0050233	molecular_function	pyranose oxidase activity
G	0050660	molecular_function	flavin adenine dinucleotide binding
H	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
H	0050233	molecular_function	pyranose oxidase activity
H	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD A 625

Chain	Residue
A	VAL52
A	VAL160
A	GLY163
A	MSE164
A	HIS167
A	TRP168
A	THR169
A	CYS170
A	ALA171
A	VAL281
A	CYS283
A	GLY53
A	THR319
A	ALA320
A	HIS324
A	LEU547
A	ASN593
A	THR595
A	HOH626
A	HOH662
A	HOH665
A	HOH686
A	GLY55
A	HOH695
A	HOH722
A	HOH743
A	HOH792
A	HOH810
A	PRO56
A	ILE57
A	ASP76
A	ILE77
A	THR158
A	ARG159

site_id	AC2
Number of Residues	36
Details	BINDING SITE FOR RESIDUE FAD B 625

Chain	Residue
B	VAL52
B	GLY53
B	GLY55
B	PRO56
B	ILE57
B	ASP76
B	ILE77
B	THR158
B	ARG159
B	VAL160
B	GLY163
B	MSE164
B	HIS167
B	TRP168
B	THR169
B	CYS170
B	ALA171
B	VAL281
B	CYS283
B	THR319
B	ALA320
B	HIS324
B	LEU547
B	HIS548
B	ASN593
B	THR595
B	HOH649
B	HOH650
B	HOH656
B	HOH663
B	HOH688
B	HOH721
B	HOH796
B	HOH804
B	HOH811
B	HOH830

site_id	AC3
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD C 625

Chain	Residue
C	HOH677
C	HOH687
C	HOH698
C	HOH756
C	VAL52
C	GLY53
C	GLY55
C	PRO56
C	ILE57
C	ASP76
C	ILE77
C	THR158
C	ARG159
C	VAL160
C	GLY163
C	MSE164
C	SER165
C	HIS167
C	TRP168
C	THR169
C	CYS170
C	ALA171
C	VAL281
C	CYS283
C	ALA320
C	HIS324
C	LEU547
C	ASN593
C	THR595
C	HOH626
C	HOH636
C	HOH641
C	HOH666

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD D 625

Chain	Residue
D	VAL52
D	GLY53
D	GLY55
D	PRO56
D	ILE57
D	ASP76
D	ILE77
D	ILE107
D	THR158
D	ARG159
D	VAL160
D	GLY163
D	MSE164
D	HIS167
D	TRP168
D	THR169
D	CYS170
D	ALA171
D	VAL281
D	CYS283
D	ALA320
D	HIS324
D	LEU547
D	ASN593
D	THR595
D	HOH630
D	HOH631
D	HOH643
D	HOH681
D	HOH685
D	HOH752

site_id	AC5
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD E 625

Chain	Residue
E	VAL52
E	GLY53
E	GLY55
E	PRO56
E	ILE57
E	ASP76
E	ILE77
E	THR158
E	ARG159
E	VAL160
E	GLY163
E	MSE164
E	HIS167
E	TRP168
E	THR169
E	CYS170
E	ALA171
E	VAL281
E	CYS283
E	THR319
E	ALA320
E	HIS324
E	LEU547
E	ASN593
E	THR595
E	HOH628
E	HOH629
E	HOH634
E	HOH636
E	HOH687
E	HOH743
E	HOH780
E	HOH783
E	HOH898

site_id	AC6
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD F 625

Chain	Residue
F	GLY53
F	GLY55
F	PRO56
F	ILE57
F	ASP76
F	ILE77
F	THR158
F	ARG159
F	VAL160
F	GLY163
F	MSE164
F	HIS167
F	TRP168
F	THR169
F	ALA171
F	VAL281
F	CYS283
F	THR319
F	ALA320
F	HIS324
F	LEU547
F	ASN593
F	THR595
F	HOH632
F	HOH656
F	HOH661
F	HOH678
F	HOH683
F	HOH706
F	HOH719
F	HOH782
F	HOH814
F	HOH825

site_id	AC7
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD G 625

Chain	Residue
G	VAL52
G	GLY53
G	GLY55
G	PRO56
G	ILE57
G	ASP76
G	ILE77
G	THR158
G	ARG159
G	VAL160
G	GLY163
G	MSE164
G	HIS167
G	TRP168
G	THR169
G	ALA171
G	VAL281
G	CYS283
G	ALA320
G	HIS324
G	ASN593
G	THR595
G	HOH628
G	HOH629
G	HOH635
G	HOH680
G	HOH717
G	HOH723
G	HOH761
G	HOH813

site_id	AC8
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD H 625

Chain	Residue
H	VAL52
H	GLY53
H	GLY55
H	PRO56
H	ILE57
H	ASP76
H	ILE77
H	THR158
H	ARG159
H	VAL160
H	GLY163
H	MSE164
H	HIS167
H	TRP168
H	THR169
H	CYS170
H	ALA171
H	VAL281
H	CYS283
H	ALA320
H	HIS324
H	LEU547
H	ASN593
H	THR595
H	HOH628
H	HOH653
H	HOH668
H	HOH689
H	HOH740
H	HOH742
H	HOH759
H	HOH775
H	HOH935
H	HOH938

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:E4QP00

Chain	Residue	Details
A	HIS548
B	HIS548
C	HIS548
D	HIS548
E	HIS548
F	HIS548
G	HIS548
H	HIS548

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE:

Chain	Residue	Details
A	ASN593
B	ASN593
C	ASN593
D	ASN593
E	ASN593
F	ASN593
G	ASN593
H	ASN593

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
A	GLN448
E	HIS450
F	GLN448
F	HIS450
G	GLN448
G	HIS450
H	GLN448
H	HIS450
A	HIS450
B	GLN448
B	HIS450
C	GLN448
C	HIS450
D	GLN448
D	HIS450
E	GLN448

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Tele-8alpha-FAD histidine

Chain	Residue	Details
A	HIS167
B	HIS167
C	HIS167
D	HIS167
E	HIS167
F	HIS167
G	HIS167
H	HIS167

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
A	ASN593
A	HIS548

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
B	ASN593
B	HIS548

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
C	ASN593
C	HIS548

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
D	ASN593
D	HIS548

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
E	ASN593
E	HIS548

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
F	ASN593
F	HIS548

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
G	ASN593
G	HIS548

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1kdg

Chain	Residue	Details
H	ASN593
H	HIS548

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)