1TZ8

The monoclinic crystal structure of transthyretin in complex with diethylstilbestrol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0032991	cellular_component	protein-containing complex
A	0035578	cellular_component	azurophil granule lumen
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0140313	molecular_function	molecular sequestering activity
B	0001523	biological_process	retinoid metabolic process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070062	cellular_component	extracellular exosome
B	0140313	molecular_function	molecular sequestering activity
C	0001523	biological_process	retinoid metabolic process
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006144	biological_process	purine nucleobase metabolic process
C	0032991	cellular_component	protein-containing complex
C	0035578	cellular_component	azurophil granule lumen
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070062	cellular_component	extracellular exosome
C	0140313	molecular_function	molecular sequestering activity
D	0001523	biological_process	retinoid metabolic process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006144	biological_process	purine nucleobase metabolic process
D	0032991	cellular_component	protein-containing complex
D	0035578	cellular_component	azurophil granule lumen
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070062	cellular_component	extracellular exosome
D	0140313	molecular_function	molecular sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO3 C 128

Chain	Residue
A	DMS129
C	ARG103
C	HOH4134
C	HOH4264

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 128

Chain	Residue
A	TRP41
A	GLU72

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 129

Chain	Residue
C	CO3128
D	TYR114
A	LYS80
A	GLY83
C	ARG21

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DES B 128

Chain	Residue
A	LEU17
A	ALA109
A	SER117
A	HOH4295
A	HOH4295
B	LYS15
B	LEU17
B	ALA109
B	SER117

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DES C 129

Chain	Residue
C	LEU17
C	ALA108
C	ALA108
C	LEU110
C	LEU110
C	SER117
C	SER117
D	SER117
D	SER117
D	DES128
D	DES128
D	GOL129

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DES D 128

Chain	Residue
C	DES129
C	DES129
D	LYS15
D	LYS15
D	LEU17
D	LEU17
D	ALA108
D	ALA109
D	ALA109
D	LEU110
D	LEU110
D	SER117
D	SER117

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 129

Chain	Residue
C	SER115
C	SER117
C	DES129
D	LEU110
D	SER112
D	SER115
D	TYR116
D	SER117
D	HOH4312

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 130

Chain	Residue
A	SER112
A	SER115
A	SER117
A	HOH4322
B	ALA19
B	LEU110
B	LEU111
B	SER112
B	SER115
B	TYR116
B	SER117

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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