1TYC
STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 11 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.ADsLHIGHL |
| Chain | Residue | Details |
| A | PRO39-LEU49 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1TYD |
| Chain | Residue | Details |
| A | TYR34 | |
| A | TYR169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250, ECO:0007744|PDB:1TYD |
| Chain | Residue | Details |
| A | GLN173 | |
| A | ASP176 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS233 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | LYS233 | |
| A | LYS230 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | ARG86 | |
| A | LYS82 | |
| A | LYS233 | |
| A | LYS230 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 197 |
| Chain | Residue | Details |
| A | THR40 | electrostatic stabiliser, hydrogen bond donor |
| A | THR234 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand |
| A | HIS45 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS48 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG86 | electrostatic stabiliser, hydrogen bond donor |
| A | GLN173 | electrostatic stabiliser, hydrogen bond acceptor |
| A | ASP194 | electrostatic stabiliser, hydrogen bond acceptor |
| A | LYS230 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS233 | electrostatic stabiliser, hydrogen bond donor |
