1TXT
Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0006696 | biological_process | ergosterol biosynthetic process |
| B | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0016746 | molecular_function | acyltransferase activity |
| C | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| C | 0006084 | biological_process | acetyl-CoA metabolic process |
| C | 0006696 | biological_process | ergosterol biosynthetic process |
| C | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| C | 0016746 | molecular_function | acyltransferase activity |
| D | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| D | 0006084 | biological_process | acetyl-CoA metabolic process |
| D | 0006696 | biological_process | ergosterol biosynthetic process |
| D | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| D | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE CAA A 5866 |
| Chain | Residue |
| A | ASP29 |
| A | PHE185 |
| A | GLY198 |
| A | SER201 |
| A | HIS233 |
| A | PRO235 |
| A | PHE236 |
| A | LYS238 |
| A | LYS242 |
| A | ASN275 |
| A | SER307 |
| A | ASN31 |
| A | HOH5897 |
| A | HOH5904 |
| A | HOH5935 |
| A | LYS32 |
| A | GLY36 |
| A | CSD111 |
| A | TYR143 |
| A | GLY148 |
| A | GLY149 |
| A | THR152 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CAA B 6866 |
| Chain | Residue |
| B | ASP29 |
| B | ASN31 |
| B | LYS32 |
| B | GLY36 |
| B | CSD111 |
| B | TYR143 |
| B | GLY148 |
| B | GLY149 |
| B | THR152 |
| B | PHE185 |
| B | SER201 |
| B | LYS202 |
| B | HIS233 |
| B | PRO235 |
| B | PHE236 |
| B | LYS238 |
| B | LYS242 |
| B | ASN275 |
| B | SER307 |
| B | HOH6933 |
| B | HOH6941 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE CAA C 7866 |
| Chain | Residue |
| C | ASP29 |
| C | ASN31 |
| C | LYS32 |
| C | GLY36 |
| C | CSD111 |
| C | TYR143 |
| C | GLY148 |
| C | THR152 |
| C | PHE185 |
| C | GLY198 |
| C | SER201 |
| C | LYS202 |
| C | HIS233 |
| C | PRO235 |
| C | PHE236 |
| C | LYS238 |
| C | LYS242 |
| C | ASN275 |
| C | SER307 |
| C | HOH7929 |
| C | HOH7931 |
| C | HOH7953 |
| C | HOH7964 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CAA D 8866 |
| Chain | Residue |
| D | ASP29 |
| D | ASN31 |
| D | LYS32 |
| D | GLY36 |
| D | ILE37 |
| D | CSD111 |
| D | TYR143 |
| D | GLY148 |
| D | THR152 |
| D | PHE185 |
| D | GLY198 |
| D | SER201 |
| D | HIS233 |
| D | PRO235 |
| D | PHE236 |
| D | LYS242 |
| D | ASN275 |
| D | SER307 |
| D | HOH8914 |
| D | HOH8933 |
| D | HOH8951 |
