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1TWH

RNA polymerase II complexed with 2'dATP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0001055molecular_functionRNA polymerase II activity
A0001172biological_processRNA-templated transcription
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005665cellular_componentRNA polymerase II, core complex
A0005739cellular_componentmitochondrion
A0006351biological_processDNA-templated transcription
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0008270molecular_functionzinc ion binding
A0010494cellular_componentcytoplasmic stress granule
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0019985biological_processtranslesion synthesis
A0034062molecular_function5'-3' RNA polymerase activity
A0046872molecular_functionmetal ion binding
B0000428cellular_componentDNA-directed RNA polymerase complex
B0001055molecular_functionRNA polymerase II activity
B0001172biological_processRNA-templated transcription
B0003677molecular_functionDNA binding
B0003729molecular_functionmRNA binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005665cellular_componentRNA polymerase II, core complex
B0005739cellular_componentmitochondrion
B0006351biological_processDNA-templated transcription
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006368biological_processtranscription elongation by RNA polymerase II
B0008270molecular_functionzinc ion binding
B0010494cellular_componentcytoplasmic stress granule
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0046872molecular_functionmetal ion binding
C0000428cellular_componentDNA-directed RNA polymerase complex
C0001055molecular_functionRNA polymerase II activity
C0001172biological_processRNA-templated transcription
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
C0003968molecular_functionRNA-dependent RNA polymerase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005665cellular_componentRNA polymerase II, core complex
C0006351biological_processDNA-templated transcription
C0006366biological_processtranscription by RNA polymerase II
C0006367biological_processtranscription initiation at RNA polymerase II promoter
C0006368biological_processtranscription elongation by RNA polymerase II
C0006369biological_processtermination of RNA polymerase II transcription
C0008270molecular_functionzinc ion binding
C0046872molecular_functionmetal ion binding
C0046983molecular_functionprotein dimerization activity
C0055029cellular_componentnuclear DNA-directed RNA polymerase complex
E0000428cellular_componentDNA-directed RNA polymerase complex
E0001054molecular_functionRNA polymerase I activity
E0001055molecular_functionRNA polymerase II activity
E0001056molecular_functionRNA polymerase III activity
E0001172biological_processRNA-templated transcription
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
E0003968molecular_functionRNA-dependent RNA polymerase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005665cellular_componentRNA polymerase II, core complex
E0005666cellular_componentRNA polymerase III complex
E0005736cellular_componentRNA polymerase I complex
E0006351biological_processDNA-templated transcription
E0006360biological_processtranscription by RNA polymerase I
E0006361biological_processtranscription initiation at RNA polymerase I promoter
E0006362biological_processtranscription elongation by RNA polymerase I
E0006363biological_processtermination of RNA polymerase I transcription
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation at RNA polymerase II promoter
E0006368biological_processtranscription elongation by RNA polymerase II
E0006383biological_processtranscription by RNA polymerase III
E0006384biological_processtranscription initiation at RNA polymerase III promoter
E0006386biological_processtermination of RNA polymerase III transcription
E0042254biological_processribosome biogenesis
E0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
E0042797biological_processtRNA transcription by RNA polymerase III
E0055029cellular_componentnuclear DNA-directed RNA polymerase complex
F0000428cellular_componentDNA-directed RNA polymerase complex
F0001054molecular_functionRNA polymerase I activity
F0001055molecular_functionRNA polymerase II activity
F0001056molecular_functionRNA polymerase III activity
F0001172biological_processRNA-templated transcription
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
F0003968molecular_functionRNA-dependent RNA polymerase activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005665cellular_componentRNA polymerase II, core complex
F0005666cellular_componentRNA polymerase III complex
F0005736cellular_componentRNA polymerase I complex
F0005737cellular_componentcytoplasm
F0006351biological_processDNA-templated transcription
F0006360biological_processtranscription by RNA polymerase I
F0006361biological_processtranscription initiation at RNA polymerase I promoter
F0006362biological_processtranscription elongation by RNA polymerase I
F0006363biological_processtermination of RNA polymerase I transcription
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0006368biological_processtranscription elongation by RNA polymerase II
F0006383biological_processtranscription by RNA polymerase III
F0006384biological_processtranscription initiation at RNA polymerase III promoter
F0006386biological_processtermination of RNA polymerase III transcription
F0042254biological_processribosome biogenesis
F0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
F0042797biological_processtRNA transcription by RNA polymerase III
H0000428cellular_componentDNA-directed RNA polymerase complex
H0001054molecular_functionRNA polymerase I activity
H0001055molecular_functionRNA polymerase II activity
H0001056molecular_functionRNA polymerase III activity
H0001172biological_processRNA-templated transcription
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
H0003968molecular_functionRNA-dependent RNA polymerase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005665cellular_componentRNA polymerase II, core complex
H0005666cellular_componentRNA polymerase III complex
H0005736cellular_componentRNA polymerase I complex
H0006351biological_processDNA-templated transcription
H0006360biological_processtranscription by RNA polymerase I
H0006361biological_processtranscription initiation at RNA polymerase I promoter
H0006362biological_processtranscription elongation by RNA polymerase I
H0006363biological_processtermination of RNA polymerase I transcription
H0006366biological_processtranscription by RNA polymerase II
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0006368biological_processtranscription elongation by RNA polymerase II
H0006383biological_processtranscription by RNA polymerase III
H0006384biological_processtranscription initiation at RNA polymerase III promoter
H0006386biological_processtermination of RNA polymerase III transcription
H0042254biological_processribosome biogenesis
H0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
H0042797biological_processtRNA transcription by RNA polymerase III
I0000428cellular_componentDNA-directed RNA polymerase complex
I0001172biological_processRNA-templated transcription
I0001193biological_processmaintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I0003676molecular_functionnucleic acid binding
I0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
I0003968molecular_functionRNA-dependent RNA polymerase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005665cellular_componentRNA polymerase II, core complex
I0005730cellular_componentnucleolus
I0006281biological_processDNA repair
I0006283biological_processtranscription-coupled nucleotide-excision repair
I0006351biological_processDNA-templated transcription
I0006366biological_processtranscription by RNA polymerase II
I0006367biological_processtranscription initiation at RNA polymerase II promoter
I0006368biological_processtranscription elongation by RNA polymerase II
I0006974biological_processDNA damage response
I0008270molecular_functionzinc ion binding
I0046872molecular_functionmetal ion binding
J0000428cellular_componentDNA-directed RNA polymerase complex
J0001054molecular_functionRNA polymerase I activity
J0001055molecular_functionRNA polymerase II activity
J0001056molecular_functionRNA polymerase III activity
J0001172biological_processRNA-templated transcription
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
J0003968molecular_functionRNA-dependent RNA polymerase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005665cellular_componentRNA polymerase II, core complex
J0005666cellular_componentRNA polymerase III complex
J0005730cellular_componentnucleolus
J0005736cellular_componentRNA polymerase I complex
J0006351biological_processDNA-templated transcription
J0006360biological_processtranscription by RNA polymerase I
J0006361biological_processtranscription initiation at RNA polymerase I promoter
J0006362biological_processtranscription elongation by RNA polymerase I
J0006363biological_processtermination of RNA polymerase I transcription
J0006366biological_processtranscription by RNA polymerase II
J0006367biological_processtranscription initiation at RNA polymerase II promoter
J0006368biological_processtranscription elongation by RNA polymerase II
J0006383biological_processtranscription by RNA polymerase III
J0006384biological_processtranscription initiation at RNA polymerase III promoter
J0006386biological_processtermination of RNA polymerase III transcription
J0008270molecular_functionzinc ion binding
J0042254biological_processribosome biogenesis
J0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
J0042797biological_processtRNA transcription by RNA polymerase III
J0046872molecular_functionmetal ion binding
K0000428cellular_componentDNA-directed RNA polymerase complex
K0001055molecular_functionRNA polymerase II activity
K0001172biological_processRNA-templated transcription
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
K0003968molecular_functionRNA-dependent RNA polymerase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005665cellular_componentRNA polymerase II, core complex
K0006351biological_processDNA-templated transcription
K0006366biological_processtranscription by RNA polymerase II
K0006367biological_processtranscription initiation at RNA polymerase II promoter
K0006368biological_processtranscription elongation by RNA polymerase II
K0006369biological_processtermination of RNA polymerase II transcription
K0046983molecular_functionprotein dimerization activity
L0000428cellular_componentDNA-directed RNA polymerase complex
L0001054molecular_functionRNA polymerase I activity
L0001055molecular_functionRNA polymerase II activity
L0001056molecular_functionRNA polymerase III activity
L0001172biological_processRNA-templated transcription
L0003677molecular_functionDNA binding
L0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
L0003968molecular_functionRNA-dependent RNA polymerase activity
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005665cellular_componentRNA polymerase II, core complex
L0005666cellular_componentRNA polymerase III complex
L0005730cellular_componentnucleolus
L0005736cellular_componentRNA polymerase I complex
L0005737cellular_componentcytoplasm
L0005777cellular_componentperoxisome
L0006351biological_processDNA-templated transcription
L0006360biological_processtranscription by RNA polymerase I
L0006361biological_processtranscription initiation at RNA polymerase I promoter
L0006362biological_processtranscription elongation by RNA polymerase I
L0006363biological_processtermination of RNA polymerase I transcription
L0006366biological_processtranscription by RNA polymerase II
L0006367biological_processtranscription initiation at RNA polymerase II promoter
L0006368biological_processtranscription elongation by RNA polymerase II
L0006383biological_processtranscription by RNA polymerase III
L0006384biological_processtranscription initiation at RNA polymerase III promoter
L0006386biological_processtermination of RNA polymerase III transcription
L0008270molecular_functionzinc ion binding
L0042254biological_processribosome biogenesis
L0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
L0042797biological_processtRNA transcription by RNA polymerase III
L0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 3009
ChainResidue
AASP481
AASP483
AASP485
AMN3010
AATP3011

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 3010
ChainResidue
BASP837
AASP481
AASP483
AMN3009
AATP3011

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 3001
ChainResidue
JCYS7
JCYS10
JCYS45
JCYS46

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 3002
ChainResidue
CCYS86
CCYS88
CCYS92
CCYS95

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 3003
ChainResidue
ICYS7
ICYS10
ICYS29
ICYS32

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 3004
ChainResidue
ICYS75
ICYS78
ICYS103
ICYS106

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN L 3005
ChainResidue
LCYS31
LCYS34
LSER36
LCYS48
LCYS51

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 3006
ChainResidue
ACYS107
ACYS110
ACYS148
AGLY166
ACYS167

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 3007
ChainResidue
BCYS1163
BCYS1166
BCYS1182
BCYS1185

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 3008
ChainResidue
ACYS67
ACYS70
ACYS77
AHIS80

site_idBC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ATP A 3011
ChainResidue
AASP481
AASP483
AASP485
AMN3009
AMN3010
BARG766
BGLN986
BLYS987
BARG1020

Functional Information from PROSITE/UniProt
site_idPS01112
Number of Residues10
DetailsRNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG
ChainResidueDetails
JILE2-GLY11

site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
ChainResidueDetails
FTHR86-GLN100

site_idPS00466
Number of Residues36
DetailsZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkChsrenvffqSQQRRkDTSmvlffvCls...CshiF
ChainResidueDetails
ICYS75-PHE110

site_idPS01030
Number of Residues27
DetailsRNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCrDCNNMLypredkennrllfeCrtC
ChainResidueDetails
IPHE6-CYS32

site_idPS00446
Number of Residues41
DetailsRNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP
ChainResidueDetails
CASN31-PRO71

site_idPS01110
Number of Residues14
DetailsRNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE
ChainResidueDetails
EHIS147-GLU160

site_idPS00115
Number of Residues7
DetailsRNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA
ChainResidueDetails
ATYR1549-ALA1555
ATYR1612-SER1618
ATYR1619-SER1625
ATYR1626-SER1632
ATYR1633-SER1639
ATYR1640-SER1646
ATYR1647-SER1653
ATYR1654-ALA1660
ATYR1661-SER1667
ATYR1668-SER1674
ATYR1675-SER1681
ATYR1556-SER1562
ATYR1682-SER1688
ATYR1689-ASN1695
ATYR1696-SER1702
ATYR1563-SER1569
ATYR1570-SER1576
ATYR1577-SER1583
ATYR1584-SER1590
ATYR1591-SER1597
ATYR1598-SER1604
ATYR1605-SER1611

site_idPS01154
Number of Residues32
DetailsRNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP
ChainResidueDetails
KPHE35-PRO66

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
ChainResidueDetails
BGLY977-THR989

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsZN_FING: C4-type
ChainResidueDetails
LCYS31-CYS51
AASP483
AASP485
JCYS10
JCYS45
JCYS46
ACYS107
ACYS110
ACYS148
ACYS167
AASP481

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
LCYS31
LCYS34
LCYS48
LCYS51
BCYS1185

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
ChainResidueDetails
ICYS7
ICYS10
ICYS29
ICYS32

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
ChainResidueDetails
ICYS75
ICYS78
ICYS103
ICYS106

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
ISER40

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 788
ChainResidueDetails
BASP837metal ligand
AASP483metal ligand
AASP485metal ligand
AHIS1085proton acceptor, proton donor

217705

PDB entries from 2024-03-27

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