1TVY
beta-1,4-galactosyltransferase mutant Met344His (M344H-Gal-T1) complex with UDP-galactose and manganese
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GDU A 404 |
| Chain | Residue |
| A | PRO187 |
| A | LYS279 |
| A | GLY292 |
| A | TRP314 |
| A | GLY315 |
| A | GLU317 |
| A | ASP318 |
| A | HIS344 |
| A | HIS347 |
| A | ASP350 |
| A | ASN353 |
| A | PHE188 |
| A | MN403 |
| A | HOH1007 |
| A | HOH1017 |
| A | HOH1041 |
| A | HOH1057 |
| A | HOH1065 |
| A | HOH1074 |
| A | HOH1098 |
| A | HOH1159 |
| A | ARG189 |
| A | ARG191 |
| A | PHE226 |
| A | ARG228 |
| A | ASP252 |
| A | VAL253 |
| A | ASP254 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GDU B 806 |
| Chain | Residue |
| B | PRO187 |
| B | PHE188 |
| B | ARG189 |
| B | ARG191 |
| B | PHE226 |
| B | ARG228 |
| B | ASP252 |
| B | VAL253 |
| B | ASP254 |
| B | LYS279 |
| B | TYR289 |
| B | GLY292 |
| B | TRP314 |
| B | GLY315 |
| B | GLU317 |
| B | HIS344 |
| B | HIS347 |
| B | ASP350 |
| B | ASN353 |
| B | MN805 |
| B | HOH1004 |
| B | HOH1005 |
| B | HOH1064 |
| B | HOH1089 |
| B | HOH1105 |
| B | HOH1149 |
| B | HOH1179 |
| B | HOH1269 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 403 |
| Chain | Residue |
| A | ASP254 |
| A | HIS344 |
| A | HIS347 |
| A | GDU404 |
| A | HOH1007 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 805 |
| Chain | Residue |
| B | ASP254 |
| B | HIS344 |
| B | HIS347 |
| B | GDU806 |
| B | HOH1004 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 900 |
| Chain | Residue |
| A | ARG265 |
| A | PHE267 |
| A | SER268 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 901 |
| Chain | Residue |
| A | HIS347 |
| A | SER348 |
| A | HOH1019 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 902 |
| Chain | Residue |
| A | ARG346 |
| A | HOH1334 |
| A | HOH1352 |
| A | HOH1360 |
| B | THR263 |
| B | ARG265 |
| B | PHE267 |
| B | HOH1085 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 904 |
| Chain | Residue |
| B | ARG265 |
| B | PHE267 |
| B | SER268 |
| B | HOH1373 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 905 |
| Chain | Residue |
| B | HIS347 |
| B | SER348 |
| B | HOH1054 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 906 |
| Chain | Residue |
| B | SER348 |
| B | ARG349 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 907 |
| Chain | Residue |
| B | LYS166 |
| B | LEU167 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MES A 860 |
| Chain | Residue |
| A | LYS230 |
| A | THR379 |
| A | ILE398 |
| A | GLY399 |
| A | THR400 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1fr8 |
| Chain | Residue | Details |
| A | ARG359 | |
| A | GLU317 | |
| A | ASP319 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1fr8 |
| Chain | Residue | Details |
| B | ARG359 | |
| B | GLU317 | |
| B | ASP319 |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 570 |
| Chain | Residue | Details |
| A | ASP252 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | ASP254 | metal ligand |
| A | TRP314 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU317 | electrostatic stabiliser, hydrogen bond acceptor |
| A | ASP318 | activator, electrostatic stabiliser, proton acceptor, proton donor |
| A | HIS344 | metal ligand |
| A | HIS347 | metal ligand |
| A | ARG349 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 570 |
| Chain | Residue | Details |
| B | ASP252 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | ASP254 | metal ligand |
| B | TRP314 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU317 | electrostatic stabiliser, hydrogen bond acceptor |
| B | ASP318 | activator, electrostatic stabiliser, proton acceptor, proton donor |
| B | HIS344 | metal ligand |
| B | HIS347 | metal ligand |
| B | ARG349 | electrostatic stabiliser, hydrogen bond donor |
