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1TU8

STructure of Onchoverca volvulus Pi-class Glutathione S-transferase with its kompetitive inhibitor s-hexyl-GSH

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0005829cellular_componentcytosol
A0006749biological_processglutathione metabolic process
A0016740molecular_functiontransferase activity
B0004364molecular_functionglutathione transferase activity
B0005829cellular_componentcytosol
B0006749biological_processglutathione metabolic process
B0016740molecular_functiontransferase activity
C0004364molecular_functionglutathione transferase activity
C0005829cellular_componentcytosol
C0006749biological_processglutathione metabolic process
C0016740molecular_functiontransferase activity
D0004364molecular_functionglutathione transferase activity
D0005829cellular_componentcytosol
D0006749biological_processglutathione metabolic process
D0016740molecular_functiontransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GTX A 2001
ChainResidue
ATYR7
ASER63
AARG95
ATYR106
AHOH2004
AHOH2111
AHOH2127
AHOH2183
BASP96
BHOH2078
APHE8
ALEU13
APHE38
ALYS42
AGLN49
ALEU50
APRO51
AGLN62

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GTX B 2002
ChainResidue
AASP96
AHOH2124
BTYR7
BPHE8
BILE10
BLEU13
BPHE38
BGLN49
BLEU50
BPRO51
BGLN62
BSER63
BARG95
BTYR106
BHOH2003
BHOH2123
BHOH2133
BHOH2175

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GTX D 2003
ChainResidue
CASP96
DTYR7
DPHE8
DILE10
DLEU13
DPHE38
DLYS42
DGLN49
DLEU50
DPRO51
DGLN62
DSER63
DARG95
DTYR106
DHOH2095
DHOH2139
DHOH2162
DHOH2181

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GTX C 2004
ChainResidue
CTYR7
CPHE8
CLEU13
CPHE38
CLYS42
CGLN49
CLEU50
CPRO51
CGLN62
CSER63
CARG95
CTYR106
CHOH2009
CHOH2129
CHOH2142
CHOH2154
DASP96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:15640152
ChainResidueDetails
ATYR7
DTYR7
DGLN49
DGLN62
AGLN49
AGLN62
BTYR7
BGLN49
BGLN62
CTYR7
CGLN49
CGLN62

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
ALYS42
BLYS42
CLYS42
DLYS42

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR7

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR7

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
CTYR7

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
DTYR7

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PDB entries from 2024-11-06

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