1TTK

NMR solution structure of omega-conotoxin MVIIA, a N-type calcium channel blocker

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 A 26

Chain	Residue
A	SER19
A	ARG21
A	CYS25

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Functional Information from PROSITE/UniProt

site_id	PS60004
Number of Residues	25
Details	OMEGA_CONOTOXIN Omega-conotoxin family signature. CKgkGaKCSrl...MYdCCTg.SCr..SGKC

Chain	Residue	Details
A	CYS1-CYS25

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	SITE: Binds Cav2.2/CACNA1B calcium channel => ECO:0000269|PubMed:34234349

Chain	Residue	Details
A	LYS4
A	ARG10
A	THR17
A	SER19
A	ARG21

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Binds Cav2.2/CACNA1B calcium channel => ECO:0000269|PubMed:30194442, ECO:0000269|PubMed:34234349, ECO:0000269|PubMed:7826361

Chain	Residue	Details
A	TYR13

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Cysteine amide => ECO:0000269|PubMed:2441741

Chain	Residue	Details
A	CYS25

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