1TRR

TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0043565	molecular_function	sequence-specific DNA binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005737	cellular_component	cytoplasm
E	0006355	biological_process	regulation of DNA-templated transcription
E	0043565	molecular_function	sequence-specific DNA binding
E	0045892	biological_process	negative regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005737	cellular_component	cytoplasm
G	0006355	biological_process	regulation of DNA-templated transcription
G	0043565	molecular_function	sequence-specific DNA binding
G	0045892	biological_process	negative regulation of DNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005737	cellular_component	cytoplasm
H	0006355	biological_process	regulation of DNA-templated transcription
H	0043565	molecular_function	sequence-specific DNA binding
H	0045892	biological_process	negative regulation of DNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0005737	cellular_component	cytoplasm
J	0006355	biological_process	regulation of DNA-templated transcription
J	0043565	molecular_function	sequence-specific DNA binding
J	0045892	biological_process	negative regulation of DNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0005737	cellular_component	cytoplasm
K	0006355	biological_process	regulation of DNA-templated transcription
K	0043565	molecular_function	sequence-specific DNA binding
K	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE TRP A 109

Chain	Residue
A	LEU41
A	HOH1304
A	HOH1404
A	HOH1406
A	HOH2304
B	ASN40
B	LEU41
B	LEU43
B	THR44
B	PRO45
B	ARG54
A	LEU43
B	THR81
B	ARG84
B	GLY85
B	SER88
C	DC8
I	DC16
A	THR44
A	ARG54
A	THR81
A	ARG84
A	GLY85
A	SER88
A	TRP110

---

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE TRP A 110

Chain	Residue
A	ASN40
A	LEU41
A	MET42
A	LEU43
A	THR44
A	ARG54
A	THR81
A	ARG84
A	GLY85
A	SER88
A	TRP109
A	HOH1304
A	HOH1404
A	HOH1406
A	HOH2304
B	ASN40
B	LEU41
B	LEU43
B	THR44
B	PRO45
B	ARG54
B	THR81
B	ARG84
B	GLY85
B	SER88
C	DC8
I	DC16

---

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE TRP E 109

Chain	Residue
D	LEU41
D	MET42
D	LEU43
D	THR44
D	ARG54
D	THR81
D	ARG84
D	GLY85
D	SER88
D	TRP109
D	HOH4304
E	ASN40
E	LEU41
E	LEU43
E	THR44
E	PRO45
E	ARG54
E	THR81
E	ARG84
E	GLY85
E	SER88
E	HOH3304
E	HOH3404
E	HOH3406
F	DC8
L	DC16

---

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE TRP D 109

Chain	Residue
E	SER88
E	TRP109
E	HOH3404
F	DC8
L	DC16
D	ASN40
D	LEU41
D	MET42
D	LEU43
D	THR44
D	ARG54
D	THR81
D	ARG84
D	GLY85
D	SER88
D	HOH4304
E	ASN40
E	LEU41
E	MET42
E	LEU43
E	THR44
E	PRO45
E	ARG54
E	THR81
E	ARG84
E	GLY85

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE TRP H 109

Chain	Residue
F	DC16
G	ARG54
G	THR81
G	ARG84
G	GLY85
G	SER88
H	ASN40
H	LEU41
H	LEU43
H	THR44
H	PRO45
H	HOH5304
H	HOH5404
H	HOH5406
I	DC8
J	ASN40
J	LEU41
J	MET42
J	LEU43
J	THR44
J	TRP109
J	HOH8304
K	ARG54
K	THR81
K	ARG84
K	GLY85
K	SER88

---

site_id	AC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE TRP G 109

Chain	Residue
C	DC16
G	ASN40
G	LEU41
G	MET42
G	LEU43
G	THR44
G	HOH6304
H	ARG54
H	THR81
H	ARG84
H	GLY85
H	SER88
J	THR81
J	ARG84
J	GLY85
J	SER88
K	ASN40
K	LEU41
K	MET42
K	LEU43
K	THR44
K	PRO45
K	TRP109
K	HOH7304
K	HOH7404
K	HOH7406
L	DC8

---

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE TRP K 109

Chain	Residue
C	DC16
G	ASN40
G	LEU41
G	MET42
G	LEU43
G	THR44
G	TRP109
H	ARG54
H	THR81
H	ARG84
H	GLY85
H	SER88
J	ARG54
J	THR81
J	ARG84
J	GLY85
J	SER88
K	ASN40
K	LEU41
K	LEU43
K	THR44
K	PRO45
K	HOH7304
K	HOH7404
K	HOH7406
L	DC8

---

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE TRP J 109

Chain	Residue
F	DC16
G	ARG54
G	THR81
G	ARG84
G	GLY85
G	SER88
H	ASN40
H	LEU41
H	MET42
H	LEU43
H	THR44
H	PRO45
H	TRP109
H	HOH5404
I	DC8
J	ASN40
J	LEU41
J	MET42
J	LEU43
J	THR44
J	HOH8304
K	ARG54
K	THR81
K	ARG84
K	GLY85
K	SER88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	DNA_BIND:

Chain	Residue	Details
A	ARG69-ALA92
B	ARG69-ALA92
D	ARG69-ALA92
E	ARG69-ALA92
G	ARG69-ALA92
H	ARG69-ALA92
J	ARG69-ALA92
K	ARG69-ALA92

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