1TR4
Solution structure of human oncogenic protein gankyrin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000502 | cellular_component | proteasome complex |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008540 | cellular_component | proteasome regulatory particle, base subcomplex |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031398 | biological_process | positive regulation of protein ubiquitination |
| A | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043409 | biological_process | negative regulation of MAPK cascade |
| A | 0043518 | biological_process | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| A | 0045737 | biological_process | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| A | 0070682 | biological_process | proteasome regulatory particle assembly |
| A | 0090201 | biological_process | negative regulation of release of cytochrome c from mitochondria |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Repeat: {"description":"ANK 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 125 |
| Details | Region: {"description":"Interaction with RB1","evidences":[{"source":"PubMed","id":"10613832","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | Region: {"description":"Required for nuclear localization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 187 |
| Details | Region: {"description":"Interaction with RELA"} |
| Chain | Residue | Details |
