1TQY

The Actinorhodin Ketosynthase/Chain Length Factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005829	cellular_component	cytosol
A	0006633	biological_process	fatty acid biosynthetic process
A	0016746	molecular_function	acyltransferase activity
A	0030497	biological_process	fatty acid elongation
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0005829	cellular_component	cytosol
C	0006633	biological_process	fatty acid biosynthetic process
C	0016746	molecular_function	acyltransferase activity
C	0030497	biological_process	fatty acid elongation
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0005829	cellular_component	cytosol
E	0006633	biological_process	fatty acid biosynthetic process
E	0016746	molecular_function	acyltransferase activity
E	0030497	biological_process	fatty acid elongation
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0006633	biological_process	fatty acid biosynthetic process
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
G	0005829	cellular_component	cytosol
G	0006633	biological_process	fatty acid biosynthetic process
G	0016746	molecular_function	acyltransferase activity
G	0030497	biological_process	fatty acid elongation
H	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
H	0006633	biological_process	fatty acid biosynthetic process
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 1091

Chain	Residue
B	PRO13
B	GLY31
B	GLN50
B	HOH1112
B	HOH1161
B	HOH1233

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 1092

Chain	Residue
D	HOH1100
D	HOH1104
D	HOH1192
D	PRO13
D	GLY31
D	GLN50

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 1093

Chain	Residue
F	PRO13
F	GLY31
F	GLN50
F	HOH1112
F	HOH1135
F	HOH1154

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA H 1094

Chain	Residue
H	PRO13
H	GLY31
H	GLN50
H	HOH1125
H	HOH1176

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1095

Chain	Residue
A	ASN307
A	ALA308
A	GLU355
A	THR400
A	VAL401

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1096

Chain	Residue
C	ASN307
C	ALA308
C	GLU355
C	THR400
C	VAL401

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 1097

Chain	Residue
E	ASN307
E	ALA308
E	GLU355
E	THR400
E	VAL401

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 1098

Chain	Residue
G	ASN307
G	ALA308
G	GLU355
G	THR400
G	VAL401

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACE A 633

Chain	Residue
A	CYS169
A	GLY404
A	PHE405

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACE C 633

Chain	Residue
C	CYS169
C	GLY404
C	PHE405

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACE E 633

Chain	Residue
E	CYS169
E	GLY404
E	PHE405

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACE G 633

Chain	Residue
G	CYS169
G	GLY404
G	PHE405

---

Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPVtmVStGCTSGldSV

Chain	Residue	Details
A	GLY160-VAL176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	HIS309
A	CYS169
A	HIS346
A	PHE405

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
C	HIS309
C	CYS169
C	HIS346
C	PHE405

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
E	HIS309
E	CYS169
E	HIS346
E	PHE405

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
G	HIS309
G	CYS169
G	HIS346
G	PHE405

---