1TQY
The Actinorhodin Ketosynthase/Chain Length Factor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0030497 | biological_process | fatty acid elongation |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0030497 | biological_process | fatty acid elongation |
| D | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
| E | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0017000 | biological_process | antibiotic biosynthetic process |
| E | 0030497 | biological_process | fatty acid elongation |
| F | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016746 | molecular_function | acyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0017000 | biological_process | antibiotic biosynthetic process |
| G | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016746 | molecular_function | acyltransferase activity |
| G | 0017000 | biological_process | antibiotic biosynthetic process |
| G | 0030497 | biological_process | fatty acid elongation |
| H | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016746 | molecular_function | acyltransferase activity |
| H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| H | 0017000 | biological_process | antibiotic biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1091 |
| Chain | Residue |
| B | PRO13 |
| B | GLY31 |
| B | GLN50 |
| B | HOH1112 |
| B | HOH1161 |
| B | HOH1233 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 1092 |
| Chain | Residue |
| D | HOH1100 |
| D | HOH1104 |
| D | HOH1192 |
| D | PRO13 |
| D | GLY31 |
| D | GLN50 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA F 1093 |
| Chain | Residue |
| F | PRO13 |
| F | GLY31 |
| F | GLN50 |
| F | HOH1112 |
| F | HOH1135 |
| F | HOH1154 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 1094 |
| Chain | Residue |
| H | PRO13 |
| H | GLY31 |
| H | GLN50 |
| H | HOH1125 |
| H | HOH1176 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1095 |
| Chain | Residue |
| A | ASN307 |
| A | ALA308 |
| A | GLU355 |
| A | THR400 |
| A | VAL401 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1096 |
| Chain | Residue |
| C | ASN307 |
| C | ALA308 |
| C | GLU355 |
| C | THR400 |
| C | VAL401 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 1097 |
| Chain | Residue |
| E | ASN307 |
| E | ALA308 |
| E | GLU355 |
| E | THR400 |
| E | VAL401 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG G 1098 |
| Chain | Residue |
| G | ASN307 |
| G | ALA308 |
| G | GLU355 |
| G | THR400 |
| G | VAL401 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACE A 633 |
| Chain | Residue |
| A | CYS169 |
| A | GLY404 |
| A | PHE405 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACE C 633 |
| Chain | Residue |
| C | CYS169 |
| C | GLY404 |
| C | PHE405 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACE E 633 |
| Chain | Residue |
| E | CYS169 |
| E | GLY404 |
| E | PHE405 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACE G 633 |
| Chain | Residue |
| G | CYS169 |
| G | GLY404 |
| G | PHE405 |
Functional Information from PROSITE/UniProt
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPVtmVStGCTSGldSV |
| Chain | Residue | Details |
| A | GLY160-VAL176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | CYS169 | |
| G | CYS169 | |
| G | HIS309 | |
| G | HIS346 | |
| A | HIS309 | |
| A | HIS346 | |
| C | CYS169 | |
| C | HIS309 | |
| C | HIS346 | |
| E | CYS169 | |
| E | HIS309 | |
| E | HIS346 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | HIS309 | |
| A | CYS169 | |
| A | HIS346 | |
| A | PHE405 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| C | HIS309 | |
| C | CYS169 | |
| C | HIS346 | |
| C | PHE405 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| E | HIS309 | |
| E | CYS169 | |
| E | HIS346 | |
| E | PHE405 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| G | HIS309 | |
| G | CYS169 | |
| G | HIS346 | |
| G | PHE405 |
