1TPH

1.8 ANGSTROMS CRYSTAL STRUCTURE OF WILD TYPE CHICKEN TRIOSEPHOSPHATE ISOMERASE-PHOSPHOGLYCOLOHYDROXAMATE COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004807	molecular_function	triose-phosphate isomerase activity
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0006094	biological_process	gluconeogenesis
1	0006096	biological_process	glycolytic process
1	0008929	molecular_function	methylglyoxal synthase activity
1	0016829	molecular_function	lyase activity
1	0016853	molecular_function	isomerase activity
1	0019242	biological_process	methylglyoxal biosynthetic process
1	0019563	biological_process	glycerol catabolic process
1	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
1	0031625	molecular_function	ubiquitin protein ligase binding
1	0042803	molecular_function	protein homodimerization activity
1	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
1	0061621	biological_process	canonical glycolysis
2	0004807	molecular_function	triose-phosphate isomerase activity
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0006094	biological_process	gluconeogenesis
2	0006096	biological_process	glycolytic process
2	0008929	molecular_function	methylglyoxal synthase activity
2	0016829	molecular_function	lyase activity
2	0016853	molecular_function	isomerase activity
2	0019242	biological_process	methylglyoxal biosynthetic process
2	0019563	biological_process	glycerol catabolic process
2	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
2	0031625	molecular_function	ubiquitin protein ligase binding
2	0042803	molecular_function	protein homodimerization activity
2	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
2	0061621	biological_process	canonical glycolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PGH 1 250

Chain	Residue
1	LYS13
1	HIS95
1	GLU165
1	ALA169
1	ILE170
1	GLY171
1	GLY210
1	SER211
1	LEU230
1	GLY232
1	GLY233
1	HOH348
1	HOH359
1	HOH382
1	HOH383
1	ASN11

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PGH 2 250

Chain	Residue
2	ASN11
2	LYS13
2	HIS95
2	GLU165
2	ALA169
2	ILE170
2	GLY171
2	GLY210
2	SER211
2	LEU230
2	GLY232
2	GLY233
2	HOH405
2	HOH415
2	HOH417
2	HOH518

---

site_id	ACT
Number of Residues	4
Details

Chain	Residue
1	GLU165
1	HIS95
1	SER96
1	LYS13

---

site_id	BCT
Number of Residues	4
Details

Chain	Residue
2	GLU165
2	HIS95
2	SER96
2	LYS13

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
1	ALA163-GLY173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Electrophile","evidences":[{"source":"PubMed","id":"8130195","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TPH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"8130195","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TPH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8130195","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TPH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 2204417, 2204418, 1569570, 8130195, 2005961

Chain	Residue	Details
1	LYS13
1	HIS95
1	ASN11
1	GLU165
1	GLY171

---

site_id	CSA2
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 2204417, 2204418, 1569570, 8130195, 2005961

Chain	Residue	Details
2	LYS13
2	HIS95
2	ASN11
2	GLU165
2	GLY171

---

site_id	MCSA1
Number of Residues	7
Details	M-CSA 324

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 324

Chain

Residue

Details

---