1TNR

CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
R	0005031	molecular_function	tumor necrosis factor receptor activity
R	0006693	biological_process	prostaglandin metabolic process
R	0006954	biological_process	inflammatory response
R	0033209	biological_process	tumor necrosis factor-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LlVPtSGIYFVysQVvF

Chain	Residue	Details
A	LEU65-PHE81

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site_id	PS00652
Number of Residues	38
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqnnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC

Chain	Residue	Details
R	CYS15-CYS52
R	CYS55-CYS96
R	CYS96-CYS137

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site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtChaGFflrene..C

Chain	Residue	Details
R	CYS137-CYS150

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	Domain: {"description":"THD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01387","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000048","evidences":[{"source":"PubMed","id":"1451807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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