1TLL
CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO3 A 1500 |
| Chain | Residue |
| A | LYS1142 |
| A | ARG1200 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO3 B 2500 |
| Chain | Residue |
| B | LYS3095 |
| B | ARG3217 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE FMN A 1451 |
| Chain | Residue |
| A | SER766 |
| A | SER807 |
| A | THR808 |
| A | PHE809 |
| A | GLY810 |
| A | GLY812 |
| A | GLY885 |
| A | SER886 |
| A | TYR889 |
| A | HIS891 |
| A | PHE892 |
| A | CYS893 |
| A | GLU919 |
| A | GLN923 |
| A | ILE1394 |
| A | FAD1452 |
| A | HOH5026 |
| A | THR761 |
| A | GLU762 |
| A | THR763 |
| A | GLY764 |
| A | LYS765 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE FAD A 1452 |
| Chain | Residue |
| A | HIS1032 |
| A | ARG1173 |
| A | TYR1174 |
| A | TYR1175 |
| A | SER1176 |
| A | THR1191 |
| A | VAL1192 |
| A | ALA1193 |
| A | TYR1197 |
| A | GLY1209 |
| A | VAL1210 |
| A | CYS1211 |
| A | SER1212 |
| A | THR1251 |
| A | ALA1254 |
| A | PHE1395 |
| A | FMN1451 |
| A | HOH5004 |
| A | HOH5008 |
| A | HOH5030 |
| A | HOH5038 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAP A 1453 |
| Chain | Residue |
| A | ARG1010 |
| A | ALA1193 |
| A | ILE1194 |
| A | VAL1195 |
| A | SER1196 |
| A | PRO1249 |
| A | GLY1250 |
| A | THR1251 |
| A | GLY1282 |
| A | CYS1283 |
| A | ARG1284 |
| A | SER1313 |
| A | ARG1314 |
| A | TYR1322 |
| A | GLN1324 |
| A | MET1354 |
| A | THR1398 |
| A | LEU1399 |
| A | ARG1400 |
| A | HOH5000 |
| A | HOH5010 |
| A | HOH5012 |
| A | HOH5127 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE FMN B 2451 |
| Chain | Residue |
| B | FAD2452 |
| B | THR2761 |
| B | GLU2762 |
| B | THR2763 |
| B | GLY2764 |
| B | LYS2765 |
| B | SER2766 |
| B | SER2807 |
| B | THR2808 |
| B | PHE2809 |
| B | GLY2810 |
| B | GLY2812 |
| B | LEU2884 |
| B | GLY2885 |
| B | SER2886 |
| B | TYR2889 |
| B | HIS2891 |
| B | PHE2892 |
| B | CYS2893 |
| B | GLU2919 |
| B | GLN2923 |
| B | ILE3394 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FAD B 2452 |
| Chain | Residue |
| B | THR3191 |
| B | VAL3192 |
| B | ALA3193 |
| B | TYR3197 |
| B | GLY3209 |
| B | VAL3210 |
| B | CYS3211 |
| B | SER3212 |
| B | ALA3254 |
| B | PHE3395 |
| B | HOH6003 |
| B | HOH6025 |
| B | HOH6026 |
| B | HOH6042 |
| B | HOH6043 |
| B | HOH6081 |
| B | HOH6083 |
| B | HOH6095 |
| B | FMN2451 |
| B | NAP2453 |
| B | HIS3032 |
| B | ARG3173 |
| B | TYR3174 |
| B | TYR3175 |
| B | SER3176 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAP B 2453 |
| Chain | Residue |
| B | FAD2452 |
| B | ARG3010 |
| B | ALA3193 |
| B | PRO3249 |
| B | THR3251 |
| B | CYS3283 |
| B | ARG3284 |
| B | SER3313 |
| B | ARG3314 |
| B | LYS3320 |
| B | TYR3322 |
| B | GLN3324 |
| B | THR3353 |
| B | MET3354 |
| B | THR3398 |
| B | LEU3399 |
| B | ARG3400 |
| B | HOH6016 |
| B | HOH6072 |
| B | HOH6091 |
| B | HOH6095 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 494 |
| Details | Domain: {"description":"FAD-binding FR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00716","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15208315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TLL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11473123","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15208315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F20","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TLL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11473123","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F20","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1fnb |
| Chain | Residue | Details |
| A | CYS1349 | |
| A | SER1176 | |
| A | ASP1393 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1fnb |
| Chain | Residue | Details |
| B | ASP3393 | |
| B | SER3176 | |
| B | CYS3349 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fnb |
| Chain | Residue | Details |
| A | TYR1175 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fnb |
| Chain | Residue | Details |
| B | TYR3175 |
