1TKG

Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with an analog of seryladenylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0043039	biological_process	tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SSA A 500

Chain	Residue
A	HIS73
A	PRO170
A	GLY171
A	ASP180
A	MET181
A	CYS182
A	ARG183
A	HOH508
A	HOH517
A	HOH611
A	ALA76
A	HIS77
A	ILE94
A	GLY95
A	PRO96
A	TYR104
A	ILE159
A	LYS169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Domain: {"description":"TGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU01228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	223
Details	Region: {"description":"Correctly edits mischarged seryl-tRNA(Thr)","evidences":[{"source":"PubMed","id":"15525511","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	61
Details	Region: {"description":"N1 domain","evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	161
Details	Region: {"description":"N2 domain, the editing domain","evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	19
Details	Region: {"description":"tRNA acceptor stem binding","evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 540

Chain

Residue

Details

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