1TJJ
Human GM2 Activator Protein PAF complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001573 | biological_process | ganglioside metabolic process |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005319 | molecular_function | lipid transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016004 | molecular_function | phospholipase activator activity |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0030290 | molecular_function | sphingolipid activator protein activity |
| A | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0160317 | cellular_component | endolysosomal intralumenal vesicle membrane |
| A | 7770043 | ||
| B | 0001573 | biological_process | ganglioside metabolic process |
| B | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| B | 0005319 | molecular_function | lipid transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016004 | molecular_function | phospholipase activator activity |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0030290 | molecular_function | sphingolipid activator protein activity |
| B | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0046479 | biological_process | glycosphingolipid catabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0160317 | cellular_component | endolysosomal intralumenal vesicle membrane |
| B | 7770043 | ||
| C | 0001573 | biological_process | ganglioside metabolic process |
| C | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| C | 0005319 | molecular_function | lipid transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005764 | cellular_component | lysosome |
| C | 0006689 | biological_process | ganglioside catabolic process |
| C | 0006869 | biological_process | lipid transport |
| C | 0008047 | molecular_function | enzyme activator activity |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0016004 | molecular_function | phospholipase activator activity |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0030290 | molecular_function | sphingolipid activator protein activity |
| C | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| C | 0035578 | cellular_component | azurophil granule lumen |
| C | 0043202 | cellular_component | lysosomal lumen |
| C | 0046479 | biological_process | glycosphingolipid catabolic process |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0160317 | cellular_component | endolysosomal intralumenal vesicle membrane |
| C | 7770043 |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 3320 |
| Chain | Residue |
| A | LPE2483 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 3321 |
| Chain | Residue |
| A | PFS2482 |
| A | LPE2483 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 3322 |
| Chain | Residue |
| B | PHE111 |
| B | PFS2484 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 3323 |
| Chain | Residue |
| B | LPE2485 |
| B | HOH3517 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT C 3324 |
| Chain | Residue |
| C | LPE2488 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 801 |
| Chain | Residue |
| A | PRO50 |
| A | LEU51 |
| A | HIS81 |
| A | CYS83 |
| C | HOH3389 |
| A | SER49 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 802 |
| Chain | Residue |
| A | HOH3456 |
| B | SER49 |
| B | PRO50 |
| B | LEU51 |
| B | HIS81 |
| B | CYS83 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 803 |
| Chain | Residue |
| C | LEU51 |
| C | HIS81 |
| C | CYS83 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE A 900 |
| Chain | Residue |
| A | SER6 |
| A | TRP7 |
| A | ASP8 |
| A | GLU12 |
| A | HOH3429 |
| A | HOH3450 |
| A | HOH3463 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE C 901 |
| Chain | Residue |
| C | SER6 |
| C | TRP7 |
| C | ASP8 |
| C | ASN9 |
| C | GLU12 |
| C | HOH3500 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PFS A 2482 |
| Chain | Residue |
| A | ILE19 |
| A | LEU24 |
| A | VAL39 |
| A | LEU57 |
| A | ILE68 |
| A | TYR116 |
| A | SER117 |
| A | LEU118 |
| A | TYR139 |
| A | ARG140 |
| A | ILE141 |
| A | ILE157 |
| A | ALA158 |
| A | ALA159 |
| A | LEU161 |
| A | IPA1503 |
| A | LPE2483 |
| A | ACT3321 |
| A | HOH3474 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PFS B 2484 |
| Chain | Residue |
| B | LEU24 |
| B | LEU37 |
| B | VAL39 |
| B | GLY41 |
| B | LEU57 |
| B | TYR116 |
| B | LEU130 |
| B | TYR139 |
| B | ARG140 |
| B | ILE141 |
| B | ILE157 |
| B | ALA158 |
| B | ALA159 |
| B | DAO1364 |
| B | LPE2485 |
| B | ACT3322 |
| B | HOH3518 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PFS C 2486 |
| Chain | Residue |
| C | ILE19 |
| C | VAL39 |
| C | LEU57 |
| C | ILE68 |
| C | LEU130 |
| C | TYR139 |
| C | ARG140 |
| C | ILE141 |
| C | ILE157 |
| C | LEU161 |
| C | LPE2488 |
| C | HOH3464 |
| site_id | BC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE LPE A 2483 |
| Chain | Residue |
| A | ALA17 |
| A | VAL18 |
| A | VAL53 |
| A | PHE82 |
| A | LEU89 |
| A | PRO106 |
| A | TYR116 |
| A | SER143 |
| A | CYS154 |
| A | ILE155 |
| A | PFS2482 |
| A | ACT3320 |
| A | ACT3321 |
| A | HOH3324 |
| A | HOH3504 |
| site_id | BC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LPE B 2485 |
| Chain | Residue |
| B | ILE19 |
| B | VAL53 |
| B | PHE82 |
| B | PRO106 |
| B | PHE111 |
| B | TYR116 |
| B | SER143 |
| B | VAL144 |
| B | LEU145 |
| B | ILE155 |
| B | PFS2484 |
| B | ACT3323 |
| B | HOH3517 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LPE C 2488 |
| Chain | Residue |
| C | VAL18 |
| C | ILE19 |
| C | VAL53 |
| C | PRO106 |
| C | TYR116 |
| C | SER143 |
| C | GLY153 |
| C | CYS154 |
| C | ILE155 |
| C | PFS2486 |
| C | ACT3324 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DAO B 1364 |
| Chain | Residue |
| B | PRO97 |
| B | PHE123 |
| B | VAL125 |
| B | PFS2484 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 1503 |
| Chain | Residue |
| A | VAL35 |
| A | PFS2482 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA C 1511 |
| Chain | Residue |
| B | LEU64 |
| C | TYR73 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA C 1514 |
| Chain | Residue |
| C | PRO126 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA B 1515 |
| Chain | Residue |
| B | PRO110 |
| B | HOH3380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
