1TIM
STRUCTURE OF TRIOSE PHOSPHATE ISOMERASE FROM CHICKEN MUSCLE
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
| Chain | Residue | Details |
| A | ALA163-GLY173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Electrophile => ECO:0000269|PubMed:8130195, ECO:0007744|PDB:1TPH |
| Chain | Residue | Details |
| A | SER96 | |
| B | SER96 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:8130195, ECO:0007744|PDB:1TPH |
| Chain | Residue | Details |
| A | PRO166 | |
| B | PRO166 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8130195, ECO:0007744|PDB:1TPH |
| Chain | Residue | Details |
| A | TRP12 | |
| A | MET14 | |
| B | TRP12 | |
| B | MET14 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 324 |
| Chain | Residue | Details |
| A | TRP12 | electrostatic stabiliser |
| A | MET14 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | SER96 | activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ARG98 | proton acceptor, proton donor, steric role |
| A | PRO166 | activator, proton acceptor, proton donor |
| A | THR172 | electrostatic stabiliser |
| A | SER211 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 324 |
| Chain | Residue | Details |
| B | TRP12 | electrostatic stabiliser |
| B | MET14 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | SER96 | activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ARG98 | proton acceptor, proton donor, steric role |
| B | PRO166 | activator, proton acceptor, proton donor |
| B | THR172 | electrostatic stabiliser |
| B | SER211 | electrostatic stabiliser, hydrogen bond donor |
