1TI7

CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION

Replaces:  1PDS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006808	biological_process	regulation of nitrogen utilization
A	0016491	molecular_function	oxidoreductase activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
A	0070402	molecular_function	NADPH binding
A	0070403	molecular_function	NAD+ binding
A	0070404	molecular_function	NADH binding
A	0070405	molecular_function	ammonium ion binding
A	0070406	molecular_function	glutamine binding
A	0090295	biological_process	nitrogen catabolite repression of transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 379

Chain	Residue
A	GLN48
A	ILE50
A	VAL53
A	HOH1150
A	HOH1481

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 380

Chain	Residue
A	SER145
A	HOH1035
A	VAL138
A	ARG139
A	LEU141
A	LEU143

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 381

Chain	Residue
A	SER111
A	SER112
A	MET113
A	VAL148
A	ALA150
A	HOH1193

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K A 382

Chain	Residue
A	SER117
A	GLY120
A	HOH1155
A	HOH1413

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 383

Chain	Residue
A	GLN140
A	GLY347
A	ASP349
A	HOH1109
A	HOH1118

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 384

Chain	Residue
A	GLN106
A	PRO208
A	VAL252
A	ASN253
A	HOH1069

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 385

Chain	Residue
A	LYS6
A	HIS30
A	ASN253
A	HOH1051
A	HOH1333

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 386

Chain	Residue
A	GLN166
A	GLU168
A	LYS251

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 387

Chain	Residue
A	TYR276
A	PHE277
A	HOH1253

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 388

Chain	Residue
A	THR241
A	TYR242
A	HOH1229
A	HOH1334

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 389

Chain	Residue
A	ASN12
A	THR14
A	VAL36
A	HIS37
A	HOH1166

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 390

Chain	Residue
A	ARG33
A	HOH1443

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 391

Chain	Residue
A	LEU169
A	ASP349
A	TRP350
A	HOH1226
A	HOH1301

---

site_id	BC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAP A 400

Chain	Residue
A	ASN12
A	THR14
A	GLY15
A	ARG16
A	GLN17
A	HIS37
A	ASN80
A	THR81
A	THR82
A	GLN84
A	ALA85
A	MET113
A	LYS131
A	ALA150
A	GLY151
A	ILE152
A	TYR153
A	ASN156
A	TYR276
A	HOH1141
A	HOH1167
A	HOH1169
A	HOH1171
A	HOH1189
A	HOH1190
A	HOH1199
A	HOH1465

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 392

Chain	Residue
A	PRO198
A	LEU201
A	GLN202
A	LYS205
A	LEU324
A	TRP325
A	GLU344
A	HOH1130
A	HOH1287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12764138","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TI7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11726498","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K6X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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