1TH8
Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0010468 | biological_process | regulation of gene expression |
A | 0016989 | molecular_function | sigma factor antagonist activity |
A | 0030435 | biological_process | sporulation resulting in formation of a cellular spore |
A | 0030436 | biological_process | asexual sporulation |
A | 0042174 | biological_process | negative regulation of sporulation resulting in formation of a cellular spore |
A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
A | 0106310 | molecular_function | protein serine kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0030435 | biological_process | sporulation resulting in formation of a cellular spore |
B | 0043856 | molecular_function | anti-sigma factor antagonist activity |
B | 0045152 | molecular_function | antisigma factor binding |
B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 602 |
Chain | Residue |
A | ASN50 |
A | ADP200 |
A | HOH636 |
B | HOH149 |
site_id | AC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP A 200 |
Chain | Residue |
A | ILE86 |
A | ALA92 |
A | SER106 |
A | GLY107 |
A | GLY109 |
A | PHE110 |
A | THR130 |
A | MG602 |
A | HOH603 |
A | HOH604 |
A | HOH612 |
A | HOH615 |
A | HOH620 |
A | HOH636 |
B | HOH149 |
A | ASN50 |
A | ALA51 |
A | HIS54 |
A | GLY55 |
A | ASP81 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250 |
Chain | Residue | Details |
B | SER58 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1l0o |
Chain | Residue | Details |
A | GLU46 | |
A | ARG105 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 760 |
Chain | Residue | Details |
A | GLU46 | activator, electrostatic stabiliser, proton acceptor |
A | ASN50 | metal ligand |
A | ARG105 | electrostatic stabiliser, polar interaction |