Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1TFW

How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001680	biological_process	tRNA 3'-terminal CCA addition
B	0003723	molecular_function	RNA binding
B	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
B	0005524	molecular_function	ATP binding
B	0008033	biological_process	tRNA processing
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0031123	biological_process	RNA 3'-end processing
B	0042245	biological_process	RNA repair
B	0046872	molecular_function	metal ion binding
B	0106354	biological_process	tRNA surveillance
B	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001680	biological_process	tRNA 3'-terminal CCA addition
C	0003723	molecular_function	RNA binding
C	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
C	0005524	molecular_function	ATP binding
C	0008033	biological_process	tRNA processing
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0031123	biological_process	RNA 3'-end processing
C	0042245	biological_process	RNA repair
C	0046872	molecular_function	metal ion binding
C	0106354	biological_process	tRNA surveillance
C	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001680	biological_process	tRNA 3'-terminal CCA addition
D	0003723	molecular_function	RNA binding
D	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
D	0005524	molecular_function	ATP binding
D	0008033	biological_process	tRNA processing
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0031123	biological_process	RNA 3'-end processing
D	0042245	biological_process	RNA repair
D	0046872	molecular_function	metal ion binding
D	0106354	biological_process	tRNA surveillance
D	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 1601

Chain	Residue
B	SER47
B	GLU59
B	ASP61
B	ATP1501

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 1602

Chain	Residue
D	GLU59
D	ASP61
D	ATP1502

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP B 1501

Chain	Residue
B	ARG50
B	GLU59
B	ASP61
B	THR130
B	HIS133
B	LYS152
B	TYR161
B	ARG224
B	MG1601
B	HOH1647
B	HOH1685
H	A73
H	C74
H	C75
B	GLY46
B	SER47

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP D 1502

Chain	Residue
D	GLY46
D	SER47
D	ARG50
D	GLU59
D	ASP61
D	THR130
D	HIS133
D	LYS152
D	TYR161
D	ARG224
D	MG1602
D	HOH1675
D	HOH1753
D	HOH1767
I	A73
I	C74
I	C75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:14592988, ECO:0000269\|PubMed:14636575, ECO:0000269\|PubMed:25640237, ECO:0007744\|PDB:1R89, ECO:0007744\|PDB:1UEU, ECO:0007744\|PDB:4X4O, ECO:0007744\|PDB:4X4Q, ECO:0007744\|PDB:4X4S

Chain	Residue	Details
A	SER47
B	SER47
C	SER47
D	SER47

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:14592988, ECO:0000269\|PubMed:14636575, ECO:0000269\|PubMed:25640237, ECO:0007744\|PDB:1R89, ECO:0007744\|PDB:1UEU, ECO:0007744\|PDB:4X4Q, ECO:0007744\|PDB:4X4S

Chain	Residue	Details
A	ARG50
C	HIS133
C	LYS152
C	TYR161
D	ARG50
D	HIS133
D	LYS152
D	TYR161
A	HIS133
A	LYS152
A	TYR161
B	ARG50
B	HIS133
B	LYS152
B	TYR161
C	ARG50

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:14592988, ECO:0007744\|PDB:1UEV

Chain	Residue	Details
A	GLU59
B	GLU59
C	GLU59
D	GLU59

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:14592988, ECO:0007744\|PDB:1R89, ECO:0007744\|PDB:1UEV

Chain	Residue	Details
A	ASP61
A	ASP110
B	ASP61
B	ASP110
C	ASP61
C	ASP110
D	ASP61
D	ASP110

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)