1TED
Crystal structure of a type III polyketide synthase PKS18 from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009715 | biological_process | chalcone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009715 | biological_process | chalcone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009715 | biological_process | chalcone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0030639 | biological_process | polyketide biosynthetic process |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009715 | biological_process | chalcone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0030639 | biological_process | polyketide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MYR A 3045 |
| Chain | Residue |
| A | MET83 |
| A | PHE224 |
| A | PRO87 |
| A | SER143 |
| A | THR144 |
| A | CYS205 |
| A | SER206 |
| A | PHE211 |
| A | ILE220 |
| A | HIS221 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MYR B 3046 |
| Chain | Residue |
| B | MET83 |
| B | PRO87 |
| B | SER143 |
| B | CYS205 |
| B | ALA209 |
| B | PHE211 |
| B | HIS221 |
| B | PHE224 |
| B | LEU266 |
| B | ILE273 |
| B | THR274 |
| B | CYS275 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MYR C 3047 |
| Chain | Residue |
| C | MET83 |
| C | SER143 |
| C | CYS205 |
| C | ASN208 |
| C | PHE211 |
| C | ILE220 |
| C | HIS221 |
| C | PHE224 |
| C | LEU266 |
| C | ILE273 |
| C | CYS275 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MYR D 3048 |
| Chain | Residue |
| D | TYR73 |
| D | ARG81 |
| D | PRO87 |
| D | SER143 |
| D | CYS205 |
| D | ASN208 |
| D | ALA209 |
| D | PHE211 |
| D | ILE220 |
| D | HIS221 |
| D | PHE224 |
| D | ILE273 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15286723","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15286723","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Important for broad specificity for aliphatic long-chain acyl-CoA starter units"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| A | CYS175 | |
| A | PHE224 | |
| A | HIS313 | |
| A | ASN346 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| B | CYS175 | |
| B | PHE224 | |
| B | HIS313 | |
| B | ASN346 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| C | CYS175 | |
| C | PHE224 | |
| C | HIS313 | |
| C | ASN346 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| D | CYS175 | |
| D | PHE224 | |
| D | HIS313 | |
| D | ASN346 |
