1TED
Crystal structure of a type III polyketide synthase PKS18 from Mycobacterium tuberculosis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0009058 | biological_process | biosynthetic process |
A | 0009715 | biological_process | chalcone biosynthetic process |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0030639 | biological_process | polyketide biosynthetic process |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0009058 | biological_process | biosynthetic process |
B | 0009715 | biological_process | chalcone biosynthetic process |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0030639 | biological_process | polyketide biosynthetic process |
C | 0006631 | biological_process | fatty acid metabolic process |
C | 0006633 | biological_process | fatty acid biosynthetic process |
C | 0009058 | biological_process | biosynthetic process |
C | 0009715 | biological_process | chalcone biosynthetic process |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0030639 | biological_process | polyketide biosynthetic process |
D | 0006631 | biological_process | fatty acid metabolic process |
D | 0006633 | biological_process | fatty acid biosynthetic process |
D | 0009058 | biological_process | biosynthetic process |
D | 0009715 | biological_process | chalcone biosynthetic process |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0030639 | biological_process | polyketide biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MYR A 3045 |
Chain | Residue |
A | MET83 |
A | PHE224 |
A | PRO87 |
A | SER143 |
A | THR144 |
A | CYS205 |
A | SER206 |
A | PHE211 |
A | ILE220 |
A | HIS221 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MYR B 3046 |
Chain | Residue |
B | MET83 |
B | PRO87 |
B | SER143 |
B | CYS205 |
B | ALA209 |
B | PHE211 |
B | HIS221 |
B | PHE224 |
B | LEU266 |
B | ILE273 |
B | THR274 |
B | CYS275 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE MYR C 3047 |
Chain | Residue |
C | MET83 |
C | SER143 |
C | CYS205 |
C | ASN208 |
C | PHE211 |
C | ILE220 |
C | HIS221 |
C | PHE224 |
C | LEU266 |
C | ILE273 |
C | CYS275 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MYR D 3048 |
Chain | Residue |
D | TYR73 |
D | ARG81 |
D | PRO87 |
D | SER143 |
D | CYS205 |
D | ASN208 |
D | ALA209 |
D | PHE211 |
D | ILE220 |
D | HIS221 |
D | PHE224 |
D | ILE273 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:15286723 |
Chain | Residue | Details |
A | CYS175 | |
B | CYS175 | |
C | CYS175 | |
D | CYS175 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15286723 |
Chain | Residue | Details |
A | HIS221 | |
B | HIS221 | |
C | HIS221 | |
D | HIS221 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | SITE: Important for broad specificity for aliphatic long-chain acyl-CoA starter units |
Chain | Residue | Details |
A | CYS205 | |
A | ALA209 | |
B | CYS205 | |
B | ALA209 | |
C | CYS205 | |
C | ALA209 | |
D | CYS205 | |
D | ALA209 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1cgk |
Chain | Residue | Details |
A | CYS175 | |
A | PHE224 | |
A | HIS313 | |
A | ASN346 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1cgk |
Chain | Residue | Details |
B | CYS175 | |
B | PHE224 | |
B | HIS313 | |
B | ASN346 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1cgk |
Chain | Residue | Details |
C | CYS175 | |
C | PHE224 | |
C | HIS313 | |
C | ASN346 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1cgk |
Chain | Residue | Details |
D | CYS175 | |
D | PHE224 | |
D | HIS313 | |
D | ASN346 |