Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019430 | biological_process | removal of superoxide radicals |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 1902515 | cellular_component | thioredoxin-disulfide reductase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD A 500 |
Chain | Residue |
A | GLY12 |
A | GLU38 |
A | GLY41 |
A | GLN42 |
A | LEU43 |
A | THR46 |
A | VAL49 |
A | ASN51 |
A | HIS83 |
A | ILE84 |
A | ALA111 |
A | SER13 |
A | THR112 |
A | GLY113 |
A | TYR118 |
A | CYS138 |
A | GLY285 |
A | ASP286 |
A | ARG293 |
A | GLN294 |
A | ALA295 |
A | SER298 |
A | GLY14 |
A | HOH602 |
A | HOH605 |
A | HOH607 |
A | HOH613 |
A | HOH615 |
A | HOH617 |
A | HOH623 |
A | HOH675 |
A | HOH767 |
A | PRO15 |
A | ALA16 |
A | TYR23 |
A | THR35 |
A | GLY36 |
A | MET37 |
Functional Information from PROSITE/UniProt
site_id | PS00573 |
Number of Residues | 21 |
Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YrnqkVaVIGGGN |
Chain | Residue | Details |
A | CYS135-ASN155 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLY36 | |
A | VAL287 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | |
Chain | Residue | Details |
A | CYS135 | |
A | CYS138 | |
A | ASP139 | |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 381 |
Chain | Residue | Details |
A | ALA136 | covalent catalysis, proton shuttle (general acid/base) |
A | ASP139 | covalent catalysis, proton shuttle (general acid/base) |
A | GLY140 | proton shuttle (general acid/base) |