1TCG
STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NH2 A 23 |
| Chain | Residue |
| A | CYS21 |
| A | ALA22 |
Functional Information from PROSITE/UniProt
| site_id | PS60013 |
| Number of Residues | 19 |
| Details | MU_CONOTOXIN Mu-conotoxin family signature. CCTPPkkCKDRQCKPQ.RCC |
| Chain | Residue | Details |
| A | CYS3-CYS21 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for binding sodium channel"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-hydroxyproline; partial","evidences":[{"source":"PubMed","id":"1991506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2069951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2410412","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
