1TA0

Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008420	molecular_function	RNA polymerase II CTD heptapeptide repeat phosphatase activity
A	0016791	molecular_function	phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 273

Chain	Residue
A	BFD96
A	ASP98
A	ASN207
A	HOH290
A	HOH380

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT A 274

Chain	Residue
A	HOH329
A	HOH374
A	SER105
A	PHE106
A	ILE120
A	TYR158

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:17157258

Chain	Residue	Details
A	BFD96

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:15304220

Chain	Residue	Details
A	ASP98

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15304220

Chain	Residue	Details
A	BFD96
A	ASN207
A	ASP98

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:15304220

Chain	Residue	Details
A	LYS190
A	THR152

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