1T90
Crystal structure of methylmalonate semialdehyde dehydrogenase from Bacillus subtilis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004491 | molecular_function | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity |
| A | 0006210 | biological_process | thymine catabolic process |
| A | 0006574 | biological_process | L-valine catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0018478 | molecular_function | malonate-semialdehyde dehydrogenase (acetylating) activity |
| A | 0019310 | biological_process | inositol catabolic process |
| B | 0004491 | molecular_function | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity |
| B | 0006210 | biological_process | thymine catabolic process |
| B | 0006574 | biological_process | L-valine catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0018478 | molecular_function | malonate-semialdehyde dehydrogenase (acetylating) activity |
| B | 0019310 | biological_process | inositol catabolic process |
| C | 0004491 | molecular_function | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity |
| C | 0006210 | biological_process | thymine catabolic process |
| C | 0006574 | biological_process | L-valine catabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0018478 | molecular_function | malonate-semialdehyde dehydrogenase (acetylating) activity |
| C | 0019310 | biological_process | inositol catabolic process |
| D | 0004491 | molecular_function | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity |
| D | 0006210 | biological_process | thymine catabolic process |
| D | 0006574 | biological_process | L-valine catabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0018478 | molecular_function | malonate-semialdehyde dehydrogenase (acetylating) activity |
| D | 0019310 | biological_process | inositol catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD A 1490 |
| Chain | Residue |
| A | ILE149 |
| A | HIS209 |
| A | VAL212 |
| A | PHE226 |
| A | VAL227 |
| A | GLY228 |
| A | SER229 |
| A | VAL232 |
| A | LEU250 |
| A | THR251 |
| A | GLY252 |
| A | ALA150 |
| A | CYS284 |
| A | GLU382 |
| A | PHE384 |
| A | ASN410 |
| A | PHE449 |
| A | HOH1504 |
| A | HOH1617 |
| A | HOH1661 |
| A | HOH1692 |
| A | PRO151 |
| A | PHE152 |
| A | ASN153 |
| A | TRP161 |
| A | LYS176 |
| A | GLU179 |
| A | ARG180 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD B 2490 |
| Chain | Residue |
| B | ILE149 |
| B | ALA150 |
| B | PRO151 |
| B | PHE152 |
| B | ASN153 |
| B | TRP161 |
| B | LYS176 |
| B | GLU179 |
| B | ARG180 |
| B | HIS209 |
| B | VAL212 |
| B | PHE226 |
| B | VAL227 |
| B | GLY228 |
| B | SER229 |
| B | VAL232 |
| B | LEU250 |
| B | THR251 |
| B | GLY252 |
| B | CYS284 |
| B | GLU382 |
| B | PHE384 |
| B | ASN410 |
| B | PHE449 |
| B | HOH2514 |
| B | HOH2703 |
| B | HOH2719 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAD C 3490 |
| Chain | Residue |
| C | ILE149 |
| C | ALA150 |
| C | PRO151 |
| C | PHE152 |
| C | ASN153 |
| C | TRP161 |
| C | LYS176 |
| C | GLU179 |
| C | HIS209 |
| C | VAL212 |
| C | PHE226 |
| C | VAL227 |
| C | GLY228 |
| C | SER229 |
| C | VAL232 |
| C | LEU250 |
| C | THR251 |
| C | GLY252 |
| C | CYS284 |
| C | GLU382 |
| C | PHE384 |
| C | ASN410 |
| C | PHE449 |
| C | HOH3498 |
| C | HOH3572 |
| C | HOH3701 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD D 4490 |
| Chain | Residue |
| D | GLY252 |
| D | CYS284 |
| D | GLU382 |
| D | PHE384 |
| D | ASN410 |
| D | PHE449 |
| D | HOH4497 |
| D | HOH4514 |
| D | HOH4594 |
| D | ILE149 |
| D | ALA150 |
| D | PRO151 |
| D | PHE152 |
| D | ASN153 |
| D | TRP161 |
| D | LYS176 |
| D | GLU179 |
| D | ARG180 |
| D | HIS209 |
| D | VAL212 |
| D | PHE226 |
| D | VAL227 |
| D | GLY228 |
| D | SER229 |
| D | VAL232 |
| D | LEU250 |
| D | THR251 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FgSAGERCMACA |
| Chain | Residue | Details |
| A | PHE277-ALA288 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P25526","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_01670","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15272169","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T90","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS284 | |
| A | ASN153 | |
| A | LEU250 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS284 | |
| B | ASN153 | |
| B | LEU250 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | CYS284 | |
| C | ASN153 | |
| C | LEU250 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | CYS284 | |
| D | ASN153 | |
| D | LEU250 |
