1T7T

Crystal structure of the androgen receptor ligand binding domain in complex with 5-alpha dihydrotestosterone

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DHT A 300

Chain	Residue
A	LEU704
A	ASN705
A	GLN711
A	MET749
A	ARG752
A	PHE764
A	THR877
A	MET895

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Interaction with coactivator LXXL and FXXFY motifs","evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Interaction with coactivator FXXLF and FXXFY motifs","evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"UniProtKB","id":"P10275","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10275","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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