Functional Information from GO Data
| Chain | GOid | namespace | contents |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005509 | molecular_function | calcium ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0007596 | biological_process | blood coagulation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 81A H 4815 |
| Chain | Residue |
| H | HIS79 |
| H | GLY258 |
| H | GLY260 |
| H | GLY268 |
| H | HOH442 |
| H | HOH472 |
| H | GLU130 |
| H | LEU132 |
| H | ASP229 |
| H | ALA230 |
| H | CYS231 |
| H | GLU232 |
| H | SER235 |
| H | TRP257 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN I OF HIRUDIN IIIA |
| Chain | Residue |
| H | PHE55 |
| H | LYS57 |
| H | GLN60 |
| H | LEU96 |
| H | ARG98 |
| H | ARG104 |
| H | THR105 |
| H | ARG106 |
| H | TYR107 |
| H | LYS113 |
| H | ILE114 |
| H | MET116 |
| H | HOH336 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| H | LEU75-CYS80 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| H | ASP229-VAL240 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
| Chain | Residue | Details |
| I | TYS298 | |
| H | ASP135 | |
| H | SER235 | |
| Chain | Residue | Details |
| H | ASN89 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP135 | |
| H | HIS79 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | GLY236 | |
| H | SER235 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | GLY233 | |
| H | SER235 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP135 | |
| H | HIS79 | |
| H | GLY233 | |
| H | SER235 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP135 | |
| H | HIS79 | |
| H | SER235 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | GLY236 | |
| H | ASP135 | |
| H | HIS79 | |
| H | SER235 | |
