1T3A

Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 422

Chain	Residue
A	HIS211
A	HIS215
A	GLU250
A	HOH502

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 422

Chain	Residue
B	HIS211
B	HIS215
B	GLU250
B	HOH451

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	ARG401

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

Chain	Residue	Details
A	THR208-LEU217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:15157097

Chain	Residue	Details
A	GLU212
B	GLU212

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ

Chain	Residue	Details
A	HIS211
A	HIS215
B	HIS211
B	HIS215

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ

Chain	Residue	Details
A	GLU250
B	GLU250

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
A	TYR350
A	ARG347
A	GLU250

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
B	TYR350
B	ARG347
B	GLU250

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