Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1T36

Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1074

Chain	Residue
A	GLU299
A	ASN301
A	PO41078
A	ADP1087
A	HOH1191

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1075

Chain	Residue
A	HOH1605
A	GLN285
A	GLU299
A	PO41078
A	ADP1087

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1076

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 1077

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH1193
A	HOH1607

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 A 1078

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	MN1074
A	MN1075
A	ADP1087
A	HOH1130
A	HOH1305
A	HOH1306

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1079

Chain	Residue
A	GLN829
A	GLU841
A	ADP1088
A	HOH1608
A	HOH1903

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1080

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1081

Chain	Residue
A	GLN93
A	MET174

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 1082

Chain	Residue
A	THR143
A	ALA144
A	HOH1202
A	HOH1203
A	HOH1204

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1083

Chain	Residue
A	TRP71
A	HOH1622

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1084

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1085

Chain	Residue
A	ALA370
A	ASN371
A	PHE900
A	PRO901
A	GLY902

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1086

Chain	Residue
A	LYS475
A	ASN485
A	PHE488

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 383

Chain	Residue
A	HOH1456
A	HOH1457
B	HIS16
B	ASP112
B	HOH3394
B	HOH3605

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 1074

Chain	Residue
C	GLU299
C	ASN301
C	MN1075
C	PO41078
C	ADP1089
C	HOH1191

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 1075

Chain	Residue
C	GLN285
C	GLU299
C	MN1074
C	PO41078
C	ADP1089
C	HOH1587

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1076

Chain	Residue
C	GLU215
C	ASN236
C	ASP238
C	ALA239
C	ILE242
C	SER247

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1077

Chain	Residue
C	ALA126
C	GLU127
C	GLU299
C	MET300
C	ASN301
C	HOH1193

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 C 1078

Chain	Residue
C	GLY175
C	HIS243
C	GLN285
C	GLU299
C	ASN301
C	ARG303
C	ARG306
C	MN1074
C	MN1075
C	ADP1089
C	HOH1191
C	HOH1301
C	MET174

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 1079

Chain	Residue
C	GLN829
C	GLU841
C	ADP1090
C	HOH1589
C	HOH1590

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1080

Chain	Residue
C	GLU761
C	HIS781
C	GLU783
C	GLN784
C	VAL787
C	SER792

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1081

Chain	Residue
C	THR173
C	MET174
C	HOH1127

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 1082

Chain	Residue
C	THR143
C	ALA144
C	HOH1201
C	HOH1202

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 1083

Chain	Residue
C	TRP71

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1084

Chain	Residue
C	ASN289
C	ASN292
C	ARG294

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 1085

Chain	Residue
C	ALA370
C	ASN371
C	PHE900
C	PRO901
C	GLY902

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1086

Chain	Residue
C	LYS475
C	ASN485
C	HOH1607

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 383

Chain	Residue
C	HOH1451
D	HIS16
D	ASP112
D	HOH2331
D	HOH2536

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 384

Chain	Residue
C	GLU549
D	PHE15
D	ASP114
D	HOH2330

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1087

Chain	Residue
C	PHE578
C	ARG845
C	ALA847
C	ARG848

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 C 1088

Chain	Residue
C	GLU560
C	ASP592

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 1074

Chain	Residue
E	GLU299
E	ASN301
E	PO41078
E	ADP1089
E	HOH1193

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 1075

Chain	Residue
E	GLN285
E	GLU299
E	PO41078
E	ADP1089
E	HOH1597

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 1076

Chain	Residue
E	GLU215
E	ASN236
E	ASP238
E	ALA239
E	ILE242
E	SER247

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 1077

Chain	Residue
E	ALA126
E	GLU127
E	GLU299
E	MET300
E	ASN301
E	HOH1193
E	HOH1195

site_id	DC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 E 1078

Chain	Residue
E	MET174
E	GLY175
E	HIS243
E	GLN285
E	GLU299
E	ASN301
E	ARG303
E	ARG306
E	MN1074
E	MN1075
E	ADP1089
E	HOH1129
E	HOH1303

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 1079

Chain	Residue
E	GLN829
E	GLU841
E	ADP1090
E	HOH1601
E	HOH1602

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 1080

Chain	Residue
E	GLU761
E	HIS781
E	GLU783
E	GLN784
E	VAL787
E	SER792

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 1081

Chain	Residue
E	ASP84
E	GLY112
E	THR114
E	HOH1095
E	HOH1605

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 1082

Chain	Residue
E	THR173
E	MET174

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 1083

Chain	Residue
E	THR143
E	ALA144
E	HOH1202
E	HOH1203

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 1084

Chain	Residue
E	TRP71

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1085

Chain	Residue
E	ASN289
E	ASN292
E	ARG294

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 1086

Chain	Residue
E	ALA370
E	ASN371
E	PHE900
E	PRO901
E	GLY902

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1087

Chain	Residue
E	LYS475
E	ASN485
E	HOH1614

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F 383

Chain	Residue
E	HOH1447
F	HIS16
F	ASP112
F	HOH1308

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F 384

Chain	Residue
E	GLU549
E	HOH1447
F	PHE15
F	ASP114
F	HOH1307

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 1088

Chain	Residue
E	ALA847
E	ARG848

site_id	FC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN G 1074

Chain	Residue
G	MET174
G	GLU299
G	ASN301
G	MN1075
G	PO41078
G	ADP1089
G	HOH1190

site_id	FC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 1075

Chain	Residue
G	GLN285
G	GLU299
G	MN1074
G	PO41078
G	ADP1089
G	HOH1549

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 1076

Chain	Residue
G	GLU215
G	ASN236
G	ASP238
G	ALA239
G	ILE242
G	SER247

site_id	FC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 1077

Chain	Residue
G	ALA126
G	GLU127
G	GLU299
G	MET300
G	ASN301
G	HOH1190
G	HOH1191

site_id	FC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 G 1078

Chain	Residue
G	MET174
G	GLY175
G	HIS243
G	GLN285
G	GLU299
G	ASN301
G	ARG303
G	ARG306
G	MN1074
G	MN1075
G	ADP1089
G	HOH1130
G	HOH1289
G	HOH1549

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 1079

Chain	Residue
G	GLN829
G	GLU841
G	ADP1090
G	HOH1550
G	HOH1551

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 1080

Chain	Residue
G	GLU761
G	HIS781
G	GLU783
G	GLN784
G	VAL787
G	SER792

site_id	GC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 1081

Chain	Residue
G	ASP84
G	GLY112
G	THR114

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 1082

Chain	Residue
G	GLN93
G	THR173
G	MET174
G	NET1092
G	HOH1122

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 1083

Chain	Residue
G	THR143
G	ALA144
G	HOH1198
G	HOH1199

site_id	GC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL G 1084

Chain	Residue
G	TRP71

site_id	GC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 1085

Chain	Residue
G	ASN289
G	ASN292
G	ARG294

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 1086

Chain	Residue
G	ASN371
G	PHE900
G	PRO901
G	GLY902
G	HOH1246

site_id	GC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 1087

Chain	Residue
G	LYS475
G	ASN485
G	PHE488
G	HOH1419

site_id	GC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K H 383

Chain	Residue
G	HOH1422
G	HOH1423
H	HIS16
H	ASP112

site_id	HC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 384

Chain	Residue
H	PHE15
H	ASP114

site_id	HC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 1088

Chain	Residue
G	ARG845
G	ALA847
G	ARG848

site_id	HC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 385

Chain	Residue
H	TRP170
H	THR171
H	GLN172

site_id	HC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP A 1087

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	THR173
A	MET174
A	GLY175
A	GLY176
A	ASP207
A	GLU208
A	LEU210
A	ILE211
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	ILE298
A	GLU299
A	THR376
A	MN1074
A	MN1075
A	PO41078
A	HOH1191
A	HOH1231
A	HOH1244
A	HOH1605

site_id	HC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 1088

Chain	Residue
A	PRO690
A	ARG715
A	MET725
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	PRO909
A	MN1079
A	HOH1499
A	HOH1522
A	HOH1526
A	HOH1608
A	HOH1609
A	HOH1903

site_id	HC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN A 1089

Chain	Residue
A	GLU783
A	ASP791
A	ALA793
A	GLU892
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH1538
A	HOH1564

site_id	HC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET A 1090

Chain	Residue
A	THR94
A	ASN97
A	ASN936

site_id	HC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE U5P A 1091

Chain	Residue
A	SER948
A	VAL949
A	LYS954
A	THR974
A	GLY976
A	THR977
A	LYS993
A	ASN1015
A	THR1016
A	THR1017
A	ASP1025
A	SER1026
A	ILE1029
A	HOH1590

site_id	HC9
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP C 1089

Chain	Residue
C	ARG129
C	ILE167
C	ARG169
C	THR173
C	MET174
C	GLY175
C	GLY176
C	GLU208
C	SER209
C	LEU210
C	ILE211
C	GLU215
C	MET240
C	GLY241
C	ILE242
C	HIS243
C	THR244
C	GLN285
C	ILE298
C	GLU299
C	THR376
C	MN1074
C	MN1075
C	PO41078
C	HOH1191
C	HOH1229
C	HOH1244
C	HOH1587

site_id	IC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP C 1090

Chain	Residue
C	ARG715
C	MET725
C	HIS754
C	PHE755
C	LEU756
C	GLU761
C	ALA785
C	GLY786
C	VAL787
C	HIS788
C	SER789
C	GLN829
C	GLU841
C	MN1079
C	HOH1515
C	HOH1516
C	HOH1589
C	HOH1590

site_id	IC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ORN C 1091

Chain	Residue
C	GLU783
C	ASP791
C	GLU892
C	LEU907
C	TYR1040
C	ASP1041
C	THR1042
C	HOH1530
C	HOH1548

site_id	IC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET C 1092

Chain	Residue
C	THR94
C	ASN97

site_id	IC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P C 1093

Chain	Residue
C	SER948
C	VAL949
C	LYS954
C	THR974
C	GLY976
C	THR977
C	LYS993
C	ASN1015
C	THR1016
C	THR1017
C	ALA1022
C	SER1026
C	ILE1029
C	HOH1576
C	HOH1846

site_id	IC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP E 1089

Chain	Residue
E	ARG129
E	ILE167
E	ARG169
E	MET174
E	GLY175
E	GLY176
E	GLU208
E	LEU210
E	ILE211
E	GLU215
E	MET240
E	GLY241
E	ILE242
E	HIS243
E	THR244
E	GLN285
E	ILE298
E	GLU299
E	THR376
E	MN1074
E	MN1075
E	PO41078
E	HOH1193
E	HOH1227
E	HOH1244
E	HOH1597

site_id	IC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP E 1090

Chain	Residue
E	PRO690
E	ARG715
E	MET725
E	HIS754
E	PHE755
E	LEU756
E	GLU761
E	ALA785
E	GLY786
E	VAL787
E	HIS788
E	SER789
E	GLN829
E	GLU841
E	MN1079
E	HOH1520
E	HOH1521
E	HOH1525
E	HOH1598
E	HOH1599
E	HOH1600
E	HOH1602

site_id	IC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN E 1091

Chain	Residue
E	GLU783
E	ASP791
E	GLU892
E	LEU907
E	TYR1040
E	ASP1041
E	THR1042
E	HOH1537
E	HOH1560
E	HOH1570

site_id	IC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET E 1092

Chain	Residue
E	GLN22
E	GLN93
E	THR94

site_id	IC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE U5P E 1093

Chain	Residue
E	SER948
E	VAL949
E	ARG950
E	LYS954
E	THR974
E	GLY976
E	THR977
E	LYS993
E	ASN1015
E	THR1016
E	THR1017
E	ASP1025
E	SER1026
E	ILE1029
E	HOH1585
E	HOH1839
E	HOH1847

site_id	JC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP G 1089

Chain	Residue
G	ARG129
G	ILE167
G	ARG169
G	THR173
G	MET174
G	GLY175
G	GLY176
G	GLU208
G	LEU210
G	ILE211
G	GLU215
G	MET240
G	GLY241
G	ILE242
G	HIS243
G	THR244
G	GLN285
G	ILE298
G	GLU299
G	THR376
G	MN1074
G	MN1075
G	PO41078
G	HOH1222
G	HOH1237
G	HOH1548
G	HOH1549

site_id	JC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP G 1090

Chain	Residue
G	ARG715
G	HIS754
G	PHE755
G	LEU756
G	GLU761
G	ALA785
G	GLY786
G	VAL787
G	HIS788
G	SER789
G	GLN829
G	GLU841
G	MN1079
G	HOH1474
G	HOH1478
G	HOH1550
G	HOH1551

site_id	JC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN G 1091

Chain	Residue
G	GLU783
G	ASP791
G	GLU892
G	LEU907
G	TYR1040
G	ASP1041
G	THR1042
G	HOH1488
G	HOH1511
G	HOH1554

site_id	JC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET G 1092

Chain	Residue
G	GLN22
G	THR94
G	ASN97
G	CL1082

site_id	JC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P G 1093

Chain	Residue
G	SER948
G	VAL949
G	LYS954
G	THR974
G	GLY976
G	THR977
G	LYS993
G	ASN1015
G	THR1016
G	THR1017
G	ALA1022
G	ASP1025
G	SER1026
G	ILE1029
G	HOH1537

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	748
Details	Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269
F	GLU355

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269
H	GLU355

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269
B	GLU355

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269
D	GLU355

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	CYS269	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	HIS353	proton shuttle (general acid/base)
B	GLU355	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	CYS269	covalent catalysis, proton shuttle (general acid/base)
C	ARG303	electrostatic stabiliser
C	ARG715	electrostatic stabiliser
C	GLU761	steric role
C	GLN829	metal ligand
C	GLU841	metal ligand
C	ASN843	metal ligand
C	ARG848	electrostatic stabiliser
D	HIS353	proton shuttle (general acid/base)
D	GLU355	steric role
C	GLU215	steric role
C	HIS243	proton shuttle (general acid/base)
C	ASN283	electrostatic stabiliser
C	GLN285	metal ligand
C	GLU299	metal ligand
C	ASN301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	CYS269	covalent catalysis, proton shuttle (general acid/base)
E	ARG303	electrostatic stabiliser
E	ARG715	electrostatic stabiliser
E	GLU761	steric role
E	GLN829	metal ligand
E	GLU841	metal ligand
E	ASN843	metal ligand
E	ARG848	electrostatic stabiliser
F	HIS353	proton shuttle (general acid/base)
F	GLU355	steric role
E	GLU215	steric role
E	HIS243	proton shuttle (general acid/base)
E	ASN283	electrostatic stabiliser
E	GLN285	metal ligand
E	GLU299	metal ligand
E	ASN301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	CYS269	covalent catalysis, proton shuttle (general acid/base)
G	ARG303	electrostatic stabiliser
G	ARG715	electrostatic stabiliser
G	GLU761	steric role
G	GLN829	metal ligand
G	GLU841	metal ligand
G	ASN843	metal ligand
G	ARG848	electrostatic stabiliser
H	HIS353	proton shuttle (general acid/base)
H	GLU355	steric role
G	GLU215	steric role
G	HIS243	proton shuttle (general acid/base)
G	ASN283	electrostatic stabiliser
G	GLN285	metal ligand
G	GLU299	metal ligand
G	ASN301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)