1T13
Crystal Structure Of Lumazine Synthase From Brucella Abortus Bound To 5-nitro-6-(D-ribitylamino)-2,4(1H,3H) pyrimidinedione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009231 | biological_process | riboflavin biosynthetic process |
| A | 0009349 | cellular_component | riboflavin synthase complex |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009231 | biological_process | riboflavin biosynthetic process |
| B | 0009349 | cellular_component | riboflavin synthase complex |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009231 | biological_process | riboflavin biosynthetic process |
| C | 0009349 | cellular_component | riboflavin synthase complex |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009231 | biological_process | riboflavin biosynthetic process |
| D | 0009349 | cellular_component | riboflavin synthase complex |
| D | 0016740 | molecular_function | transferase activity |
| E | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009231 | biological_process | riboflavin biosynthetic process |
| E | 0009349 | cellular_component | riboflavin synthase complex |
| E | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 190 |
| Chain | Residue |
| A | ILE82 |
| A | ASP83 |
| A | GLY84 |
| A | GLY85 |
| A | ILE86 |
| A | TYR87 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 191 |
| Chain | Residue |
| B | GLY85 |
| B | ILE86 |
| B | TYR87 |
| B | ILE82 |
| B | ASP83 |
| B | GLY84 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 192 |
| Chain | Residue |
| C | ASP83 |
| C | GLY84 |
| C | GLY85 |
| C | ILE86 |
| C | TYR87 |
| C | INI202 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 193 |
| Chain | Residue |
| D | ASP83 |
| D | GLY84 |
| D | GLY85 |
| D | ILE86 |
| D | TYR87 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 194 |
| Chain | Residue |
| E | ILE82 |
| E | ASP83 |
| E | GLY84 |
| E | GLY85 |
| E | ILE86 |
| E | TYR87 |
| E | INI201 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE INI E 201 |
| Chain | Residue |
| D | LEU112 |
| D | SER113 |
| E | ALA20 |
| E | TRP22 |
| E | GLY55 |
| E | ALA56 |
| E | TYR57 |
| E | GLU58 |
| E | PHE80 |
| E | VAL81 |
| E | ILE82 |
| E | PO4194 |
| E | HOH2110 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE INI C 202 |
| Chain | Residue |
| B | LEU112 |
| B | SER113 |
| C | ALA20 |
| C | TRP22 |
| C | GLY55 |
| C | ALA56 |
| C | TYR57 |
| C | GLU58 |
| C | PHE80 |
| C | VAL81 |
| C | ILE82 |
| C | PO4192 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE INI A 203 |
| Chain | Residue |
| A | ALA20 |
| A | TRP22 |
| A | GLY55 |
| A | ALA56 |
| A | TYR57 |
| A | GLU58 |
| A | PHE80 |
| A | VAL81 |
| A | ILE82 |
| A | HOH2023 |
| E | LEU112 |
| E | SER113 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE INI D 204 |
| Chain | Residue |
| C | LEU112 |
| C | SER113 |
| D | ALA20 |
| D | TRP22 |
| D | GLY55 |
| D | ALA56 |
| D | TYR57 |
| D | GLU58 |
| D | PHE80 |
| D | VAL81 |
| D | ILE82 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE INI B 205 |
| Chain | Residue |
| A | LEU112 |
| A | SER113 |
| B | ALA20 |
| B | TRP22 |
| B | GLY55 |
| B | ALA56 |
| B | TYR57 |
| B | GLU58 |
| B | PHE80 |
| B | VAL81 |
| B | ILE82 |
| B | HOH2052 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00178","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00178","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| A | ARG88 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| B | ARG88 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| C | ARG88 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| D | ARG88 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| E | ARG88 |
