1SX7

Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RB A 601

Chain	Residue
A	ASP89
A	LEU91
A	GLU96
A	HOH1063
A	HOH1113
A	HOH1227
A	HOH1229

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RB A 602

Chain	Residue
A	HOH1016
A	HOH1018
A	HOH1087
A	GLU11
A	TYR18

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RB A 603

Chain	Residue
A	GLY30
A	PHE104
A	ARG137
A	HOH1031
A	HOH1044
A	HOH1045
A	HOH1135
A	HOH1224

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RB A 604

Chain	Residue
A	SER44
A	GLY113
A	THR115
A	HOH1211

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RB A 605

Chain	Residue
A	TYR25
A	PRO37
A	HOH1151
A	HOH1184

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 611

Chain	Residue
A	ARG125
A	TRP126
A	ASP127
A	GLU128
A	HOH1176

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL A 612

Chain	Residue
A	LYS124
A	THR142
A	PRO143
A	ASN144
A	ARG145
A	HOH1020
A	HOH1143

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 613

Chain	Residue
A	ASN132
A	LYS135
A	HOH1027

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 614

Chain	Residue
A	HIS31
A	LYS135
A	HOH1079

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 599

Chain	Residue
A	VAL71
A	VAL75
A	TYR88

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 600

Chain	Residue
A	ASN68
A	ALA72
A	ILE100
A	HOH1127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 206l

Chain	Residue	Details
A	GLU11
A	ASP20

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU11	proton shuttle (general acid/base)
A	ASP20	covalent catalysis

---