1SWZ

Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 168

Chain	Residue
A	ARG76
A	ARG80
A	LYS85
A	ASP89
A	HOH1071
A	HOH1078

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RB A 601

Chain	Residue
A	HOH1006
A	HOH1080
A	HOH1211
A	HOH1247
A	ASP89
A	LEU91
A	GLU96

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RB A 602

Chain	Residue
A	GLU11
A	TYR18
A	HOH1121
A	HOH1204
A	HOH1212

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE RB A 603

Chain	Residue
A	GLY30
A	PHE104
A	GLN105
A	HOH1058
A	HOH1122
A	HOH1208

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RB A 604

Chain	Residue
A	SER44
A	GLY113
A	THR115
A	HOH1282

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RB A 605

Chain	Residue
A	TYR25
A	PRO37
A	HOH1206
A	HOH1207

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 611

Chain	Residue
A	ARG125
A	TRP126
A	ASP127
A	GLU128
A	HOH1063
A	HOH1711

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL A 612

Chain	Residue
A	LYS124
A	THR142
A	PRO143
A	ASN144
A	ARG145
A	HOH1004
A	HOH1287

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 613

Chain	Residue
A	ASN132
A	LYS135
A	HOH1034

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 614

Chain	Residue
A	HIS31
A	LYS135
A	HOH1017

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 599

Chain	Residue
A	VAL71
A	VAL75
A	TYR88

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 600

Chain	Residue
A	ASN68
A	ALA72
A	ILE100

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU11

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP20

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU32
A	PHE104

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER117
A	ASN132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU11	proton shuttle (general acid/base)
A	ASP20	covalent catalysis

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