Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1SVM

Co-crystal structure of SV40 large T antigen helicase domain and ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
C	0003677	molecular_function	DNA binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
D	0003677	molecular_function	DNA binding
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
E	0003677	molecular_function	DNA binding
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
F	0003677	molecular_function	DNA binding
F	0005524	molecular_function	ATP binding
F	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 700

Chain	Residue
A	CYS302
A	CYS305
A	HIS313
A	HIS317

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 700

Chain	Residue
B	CYS302
B	CYS305
B	HIS313
B	HIS317

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 700

Chain	Residue
C	CYS305
C	HIS313
C	HIS317
C	CYS302

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 700

Chain	Residue
D	CYS302
D	CYS305
D	HIS313
D	HIS317

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 700

Chain	Residue
E	CYS302
E	CYS305
E	HIS313
E	HIS317

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 700

Chain	Residue
F	CYS302
F	CYS305
F	HIS313
F	HIS317

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 750

Chain	Residue
A	THR433
A	GLU473
A	ATP800
A	HOH802
A	HOH935
A	HOH936

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 750

Chain	Residue
B	THR433
B	ATP800
B	HOH937
B	HOH938
B	HOH939

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 750

Chain	Residue
C	THR433
C	ATP800
C	HOH803
C	HOH811
C	HOH926

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 750

Chain	Residue
D	THR433
D	ATP800
D	HOH801
D	HOH921
D	HOH922

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG E 750

Chain	Residue
D	HOH823
E	THR433
E	GLU473
E	ASP474
E	ATP800
E	HOH957
E	HOH958

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 750

Chain	Residue
F	THR433
F	ATP800
F	HOH805
F	HOH808
F	HOH922

site_id	BC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ATP A 800

Chain	Residue
A	LEU397
A	ILE428
A	ASP429
A	SER430
A	GLY431
A	LYS432
A	THR433
A	THR434
A	ASP474
A	ASN529
A	ARG548
A	PRO549
A	LYS550
A	LEU553
A	LEU557
A	LEU564
A	MG750
A	HOH802
A	HOH910
A	HOH935
A	HOH936
F	LYS418
F	ARG540
F	HOH846
F	HOH921

site_id	BC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ATP B 800

Chain	Residue
B	LEU557
B	LEU564
B	MG750
B	HOH804
B	HOH813
B	HOH893
B	HOH937
B	HOH938
B	HOH939
B	HOH940
A	LYS418
A	ARG540
A	HOH837
B	LEU397
B	ILE428
B	ASP429
B	SER430
B	GLY431
B	LYS432
B	THR433
B	THR434
B	ASP474
B	ASN529
B	ARG548
B	PRO549
B	LYS550
B	LEU553

site_id	BC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP C 800

Chain	Residue
B	LYS418
B	ARG540
B	HOH827
C	LEU397
C	ILE428
C	ASP429
C	SER430
C	GLY431
C	LYS432
C	THR433
C	THR434
C	ASP474
C	ASN529
C	ARG548
C	PRO549
C	LYS550
C	LEU553
C	LEU557
C	LEU564
C	MG750
C	HOH803
C	HOH811
C	HOH822
C	HOH860
C	HOH862
C	HOH925

site_id	BC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ATP D 800

Chain	Residue
C	LYS418
C	ARG540
C	HOH812
C	HOH927
D	LEU397
D	ILE428
D	ASP429
D	SER430
D	GLY431
D	LYS432
D	THR433
D	THR434
D	ASP474
D	ASN529
D	ARG548
D	PRO549
D	LYS550
D	LEU553
D	LEU557
D	LEU564
D	MG750
D	HOH801
D	HOH831
D	HOH843
D	HOH921

site_id	BC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP E 800

Chain	Residue
D	LYS418
D	ARG540
D	HOH823
D	HOH923
E	LEU397
E	ILE428
E	ASP429
E	SER430
E	GLY431
E	LYS432
E	THR433
E	THR434
E	ASP474
E	ASN529
E	ARG548
E	PRO549
E	LYS550
E	LEU553
E	LEU557
E	LEU564
E	MG750
E	HOH886
E	HOH916
E	HOH950
E	HOH958
E	HOH959

site_id	BC9
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP F 800

Chain	Residue
E	LYS418
E	ARG540
E	HOH849
E	HOH866
E	HOH868
F	LEU397
F	ILE428
F	ASP429
F	SER430
F	GLY431
F	LYS432
F	THR433
F	THR434
F	ASP474
F	ASN529
F	ARG548
F	PRO549
F	LYS550
F	LEU553
F	LEU557
F	LEU564
F	MG750
F	HOH805
F	HOH808
F	HOH815
F	HOH818

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	552
Details	ZN_FING: T-ag D1-type => ECO:0000255\|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	THR265-ARG357
B	THR265-ARG357
C	THR265-ARG357
D	THR265-ARG357
E	THR265-ARG357
F	THR265-ARG357

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	CYS302
C	CYS305
C	HIS313
C	HIS317
D	CYS302
D	CYS305
D	HIS313
D	HIS317
E	CYS302
E	CYS305
E	HIS313
A	CYS305
E	HIS317
F	CYS302
F	CYS305
F	HIS313
F	HIS317
A	HIS313
A	HIS317
B	CYS302
B	CYS305
B	HIS313
B	HIS317
C	CYS302

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00551

Chain	Residue	Details
A	GLY426
B	GLY426
C	GLY426
D	GLY426
E	GLY426
F	GLY426

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)