1SVL

Co-crystal structure of SV40 large T antigen helicase domain and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
C	0003677	molecular_function	DNA binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 700

Chain	Residue
A	CYS302
A	CYS305
A	HIS313
A	HIS317

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 700

Chain	Residue
B	CYS302
B	CYS305
B	HIS313
B	HIS317

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 700

Chain	Residue
C	CYS305
C	HIS313
C	HIS317
C	CYS302

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 750

Chain	Residue
A	HOH165
A	HOH227
A	HOH229
A	HOH230
A	THR433
A	GLU473
A	ADP800

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 750

Chain	Residue
B	HOH222
B	HOH223
B	HOH224
B	THR433
B	ADP800
C	HOH125

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG C 750

Chain	Residue
A	ARG498
C	HOH48
C	HOH216
C	HOH217
C	HOH218
C	THR433
C	ADP800

---

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP A 800

Chain	Residue
A	HOH227
A	HOH229
A	ILE428
A	ASP429
A	SER430
A	GLY431
A	LYS432
A	THR433
A	THR434
A	ARG548
A	PRO549
A	LYS550
A	LEU553
A	LEU557
A	LEU564
A	MG750
B	LYS418

---

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP B 800

Chain	Residue
B	HOH220
B	HOH222
B	HOH223
B	HOH224
B	LEU397
B	ILE428
B	ASP429
B	SER430
B	GLY431
B	LYS432
B	THR433
B	THR434
B	ARG548
B	PRO549
B	LYS550
B	LEU553
B	LEU557
B	LEU564
B	MG750
C	LYS418
C	ARG498

---

site_id	AC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP C 800

Chain	Residue
A	LYS418
A	ARG498
C	HOH33
C	HOH54
C	HOH216
C	HOH217
C	HOH218
C	LEU397
C	PRO427
C	ILE428
C	ASP429
C	SER430
C	GLY431
C	LYS432
C	THR433
C	THR434
C	ARG548
C	PRO549
C	LYS550
C	LEU553
C	LEU557
C	MG750

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Domain: {"description":"SF3 helicase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00551","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	Zinc finger: {"description":"T-ag D1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00671","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	594
Details	Region: {"description":"ATPase activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00671","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00551","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---