1SUV

Structure of Human Transferrin Receptor-Transferrin Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004998	molecular_function	transferrin receptor activity
A	0033572	biological_process	transferrin transport
B	0004998	molecular_function	transferrin receptor activity
B	0033572	biological_process	transferrin transport
C	0005576	cellular_component	extracellular region
D	0005576	cellular_component	extracellular region
E	0005576	cellular_component	extracellular region
F	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 C 338

Chain	Residue
C	ASP63
C	TYR95
C	THR120
C	ARG124
C	ALA126
C	GLY127
C	TYR188
C	HIS249
C	FE339

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE C 339

Chain	Residue
C	ASP63
C	TYR95
C	TYR188
C	HIS249
C	CO3338

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 D 338

Chain	Residue
D	ASP63
D	TYR95
D	THR120
D	ARG124
D	ALA126
D	GLY127
D	TYR188
D	HIS249
D	FE339

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 339

Chain	Residue
D	ASP63
D	TYR95
D	TYR188
D	HIS249
D	CO3338

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CO3 E 701

Chain	Residue
E	ASP392
E	TYR425
E	THR451
E	ARG455
E	THR456
E	ALA457
E	GLY458
E	TYR514
E	HIS582
E	FE703

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE E 703

Chain	Residue
E	ASP392
E	TYR425
E	TYR514
E	HIS582
E	CO3701

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CO3 F 701

Chain	Residue
F	ASP392
F	TYR425
F	THR451
F	ARG455
F	THR456
F	ALA457
F	GLY458
F	TYR514
F	HIS582
F	FE703

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE F 703

Chain	Residue
F	ASP392
F	TYR425
F	TYR514
F	HIS582
F	CO3701

---

Functional Information from PROSITE/UniProt

site_id	PS00205
Number of Residues	10
Details	TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKD

Chain	Residue	Details
C	TYR95-ASP104
E	TYR425-SER434

---

site_id	PS00206
Number of Residues	17
Details	TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLkdgaGDVAF

Chain	Residue	Details
C	TYR188-PHE204
E	TYR514-PHE529

---

site_id	PS00207
Number of Residues	31
Details	TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. QYeLLClDntrkp...VdeykdChlAqvpsHtVV

Chain	Residue	Details
C	GLN222-VAL252
E	ASP555-VAL585

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Domain: {"description":"PA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	382
Details	Region: {"description":"Ligand-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"Cell attachment site; required for binding to transferrin"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000173","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7780197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	644
Details	Domain: {"description":"Transferrin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V83","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"P12346","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) serine","featureId":"CAR_000073"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
A	GLY456

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
B	GLY456

---