1SU2
CRYSTAL STRUCTURE OF THE NUDIX HYDROLASE DR1025 IN COMPLEX WITH ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0008828 | molecular_function | dATP diphosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0008828 | molecular_function | dATP diphosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 201 |
| Chain | Residue |
| A | LEU13 |
| A | ARG14 |
| A | ALA51 |
| A | ATP357 |
| A | HOH720 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | ATP257 |
| A | MET1 |
| B | SER49 |
| B | GLY50 |
| B | ARG95 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 203 |
| Chain | Residue |
| B | LEU13 |
| B | ARG14 |
| B | ALA51 |
| B | ATP257 |
| B | HOH713 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 204 |
| Chain | Residue |
| A | SER49 |
| A | GLY50 |
| A | ARG95 |
| A | ATP357 |
| B | MET1 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 205 |
| Chain | Residue |
| A | GLU65 |
| A | HOH771 |
| A | HOH816 |
| A | HOH827 |
| A | HOH889 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 206 |
| Chain | Residue |
| B | GLU65 |
| B | HOH764 |
| B | HOH782 |
| B | HOH853 |
| B | HOH871 |
| B | HOH980 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ATP B 257 |
| Chain | Residue |
| A | MET1 |
| A | GLU2 |
| A | ASP4 |
| A | ARG6 |
| B | LEU13 |
| B | ALA15 |
| B | GLY50 |
| B | ALA51 |
| B | PHE87 |
| B | ASP89 |
| B | VAL91 |
| B | ILE93 |
| B | MG202 |
| B | MG203 |
| B | HOH791 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATP A 357 |
| Chain | Residue |
| A | LEU13 |
| A | ALA15 |
| A | ALA51 |
| A | PHE87 |
| A | ASP89 |
| A | VAL91 |
| A | ILE93 |
| A | ARG95 |
| A | MG201 |
| A | MG204 |
| A | HOH793 |
| A | HOH996 |
| B | MET1 |
| B | GLU2 |
| B | ASP4 |
| B | ARG6 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GavedgEnpqdAAvREAcEEtG |
| Chain | Residue | Details |
| A | GLY50-GLY71 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 266 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15123424","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15123424","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15123424","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
