1ST4
Structure of DcpS bound to m7GpppA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0004532 | molecular_function | RNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| A | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| B | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000932 | cellular_component | P-body |
| B | 0004532 | molecular_function | RNA exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| B | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE YT3 A 501 |
| Chain | Residue |
| A | ASP74 |
| A | ASP76 |
| A | GLU92 |
| A | YT3502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE YT3 A 502 |
| Chain | Residue |
| A | ASP74 |
| A | ASP76 |
| A | GLU92 |
| A | YT3501 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE YT3 A 503 |
| Chain | Residue |
| A | ASP76 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GTA A 451 |
| Chain | Residue |
| A | ARG54 |
| A | PHE63 |
| A | ILE83 |
| A | THR130 |
| A | TRP175 |
| A | GLU185 |
| A | PRO204 |
| A | ASP205 |
| A | LEU206 |
| A | LYS207 |
| A | HIS268 |
| A | PRO271 |
| A | SER272 |
| A | TYR273 |
| A | ASN277 |
| A | HIS279 |
| A | ARG294 |
| A | HOH519 |
| A | HOH575 |
| A | HOH599 |
| A | HOH702 |
| A | HOH730 |
| B | TYR113 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GTA B 452 |
| Chain | Residue |
| B | ARG145 |
| B | GLN146 |
| B | TRP175 |
| B | GLU185 |
| B | PRO204 |
| B | ASP205 |
| B | LEU206 |
| B | LYS207 |
| B | TYR217 |
| B | HIS268 |
| B | PRO271 |
| B | SER272 |
| B | TYR273 |
| B | ASN277 |
| B | HIS279 |
| B | ARG294 |
| B | ARG322 |
| B | HOH563 |
| B | HOH605 |
| B | HOH619 |
| B | HOH621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| B | ASN277 | |
| A | ASN277 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15068804, ECO:0000269|PubMed:15769464 |
| Chain | Residue | Details |
| B | TRP175 | |
| B | GLU185 | |
| B | ASP205 | |
| B | LYS207 | |
| A | TRP175 | |
| A | GLU185 | |
| A | ASP205 | |
| A | LYS207 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | HIS268 | |
| A | HIS268 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| B | ALA2 | |
| A | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER24 | |
| A | SER24 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DAR7 |
| Chain | Residue | Details |
| B | SER101 | |
| A | SER101 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS138 | |
| B | LYS142 | |
| A | LYS138 | |
| A | LYS142 |
