1SQQ
Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0046872 | molecular_function | metal ion binding |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0006508 | biological_process | proteolysis |
B | 0046872 | molecular_function | metal ion binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
C | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0020037 | molecular_function | heme binding |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0031966 | cellular_component | mitochondrial membrane |
C | 0045275 | cellular_component | respiratory chain complex III |
C | 0046872 | molecular_function | metal ion binding |
C | 0048039 | molecular_function | ubiquinone binding |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0009055 | molecular_function | electron transfer activity |
D | 0020037 | molecular_function | heme binding |
E | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
E | 0016020 | cellular_component | membrane |
E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
F | 0005739 | cellular_component | mitochondrion |
F | 0005743 | cellular_component | mitochondrial inner membrane |
F | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
F | 0045275 | cellular_component | respiratory chain complex III |
G | 0005739 | cellular_component | mitochondrion |
G | 0005743 | cellular_component | mitochondrial inner membrane |
G | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
G | 0045275 | cellular_component | respiratory chain complex III |
H | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
I | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
J | 0005739 | cellular_component | mitochondrion |
J | 0005743 | cellular_component | mitochondrial inner membrane |
J | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
J | 0045275 | cellular_component | respiratory chain complex III |
K | 0005739 | cellular_component | mitochondrion |
K | 0005743 | cellular_component | mitochondrial inner membrane |
K | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HEC C 381 |
Chain | Residue |
C | GLN44 |
C | GLY130 |
C | LEU133 |
C | PRO134 |
C | PHE179 |
C | HIS182 |
C | PHE183 |
C | PRO186 |
C | GLY48 |
C | LEU51 |
C | ARG80 |
C | HIS83 |
C | ALA87 |
C | PHE90 |
C | THR126 |
C | ALA127 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE HEC C 382 |
Chain | Residue |
C | TRP31 |
C | GLY34 |
C | LEU37 |
C | HIS97 |
C | VAL98 |
C | ARG100 |
C | SER106 |
C | TRP113 |
C | GLY116 |
C | VAL117 |
C | LEU119 |
C | HIS196 |
C | LEU200 |
C | SER205 |
C | ASN206 |
C | UQ2383 |
C | HOH1001 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UQ2 C 383 |
Chain | Residue |
C | PHE18 |
C | ILE27 |
C | SER35 |
C | ALA193 |
C | LEU197 |
C | HIS201 |
C | SER205 |
C | PHE220 |
C | ASP228 |
C | HEC382 |
C | HOH1006 |
C | HOH1007 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE OST C 384 |
Chain | Residue |
C | PHE128 |
C | TYR131 |
C | VAL132 |
C | GLY142 |
C | ALA143 |
C | ILE146 |
C | ILE268 |
C | LYS269 |
C | PRO270 |
C | GLU271 |
C | TYR273 |
C | PHE274 |
C | LEU294 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE HEC D 242 |
Chain | Residue |
D | CYS37 |
D | CYS40 |
D | HIS41 |
D | ASN105 |
D | LEU109 |
D | PRO110 |
D | PRO111 |
D | ARG120 |
D | TYR126 |
D | GLY159 |
D | MET160 |
D | PRO163 |
D | ILE164 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE FES E 197 |
Chain | Residue |
E | CYS139 |
E | HIS141 |
E | LEU142 |
E | CYS144 |
E | CYS158 |
E | HIS161 |
E | GLY162 |
E | SER163 |
Functional Information from PROSITE/UniProt
site_id | PS00143 |
Number of Residues | 24 |
Details | INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT |
Chain | Residue | Details |
B | GLY54-THR77 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 11 |
Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:9651245 |
Chain | Residue | Details |
K | MET1-GLN12 | |
C | TRP77-VAL98 | |
C | TRP113-LEU133 | |
C | PHE178-LEU198 | |
C | ILE226-ALA246 | |
C | LEU288-HIS308 | |
C | LEU320-GLY340 | |
C | TYR347-PRO367 |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:9651245 |
Chain | Residue | Details |
K | LEU13-ALA35 | |
F | TYR83 | |
F | GLU96 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:9651245 |
Chain | Residue | Details |
K | THR36-ASP56 | |
F | SER88 |
site_id | SWS_FT_FI4 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9651245, ECO:0007744|PDB:1BE3, ECO:0007744|PDB:1BGY |
Chain | Residue | Details |
E | CYS139 | |
E | HIS141 | |
E | CYS158 | |
E | HIS161 | |
E | SER163 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0007744|PDB:1PP9, ECO:0007744|PDB:1SQV, ECO:0007744|PDB:2A06, ECO:0007744|PDB:2YBB |
Chain | Residue | Details |
C | HIS201 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
E | HIS161 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
A | GLU60 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
B | ARG70 |