1SQ2

Crystal Structure Analysis of the Nurse Shark New Antigen Receptor (NAR) Variable Domain in Complex With Lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0003796	molecular_function	lysozyme activity
L	0003824	molecular_function	catalytic activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0005794	cellular_component	Golgi apparatus
L	0016231	molecular_function	beta-N-acetylglucosaminidase activity
L	0016787	molecular_function	hydrolase activity
L	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
L	0016998	biological_process	cell wall macromolecule catabolic process
L	0031640	biological_process	killing of cells of another organism
L	0042742	biological_process	defense response to bacterium
L	0042802	molecular_function	identical protein binding
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
N	0002250	biological_process	adaptive immune response
N	0002376	biological_process	immune system process
N	0042101	cellular_component	T cell receptor complex
N	0042605	molecular_function	peptide antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL L 130

Chain	Residue
L	ASN44
L	ARG45
L	EDO202
N	LYS12
N	HOH252
N	HOH267

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO L 201

Chain	Residue
L	PRO79
L	HOH262
L	ASN74
L	ASN77
L	ILE78

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO L 202

Chain	Residue
L	THR43
L	ASN44
L	ARG45
L	CL130
L	HOH221
L	HOH222
L	HOH309
N	HOH242

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO L 203

Chain	Residue
L	THR47
L	HOH295
N	ASN21
N	CYS22
N	SER65
N	PHE66
N	SER67
N	HOH217

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO N 204

Chain	Residue
L	ALA42
L	THR43
L	HOH255
N	GLU16
N	HOH242

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO L 205

Chain	Residue
L	THR47
L	PRO79
L	SER81
L	ALA82
L	HOH307
N	THR58

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
L	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 132l

Chain	Residue	Details
L	GLU35
L	ASP52

---

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain

Residue

Details

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