1SPH
REFINED STRUCTURES OF THE ACTIVE S83C AND IMPAIRED S46D HPRS: EVIDENCE THAT PHOSPHORYLATION DOES NOT REQUIRE A BACKBONE CONFORMATIONAL TRANSITION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0043610 | biological_process | regulation of carbohydrate utilization |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0043610 | biological_process | regulation of carbohydrate utilization |
Functional Information from PDB Data
| site_id | ACA |
| Number of Residues | 1 |
| Details | ACTIVE SITE HISTIDINE IN CHAIN A |
| Chain | Residue |
| A | HIS15 |
| site_id | ACB |
| Number of Residues | 1 |
| Details | ACTIVE SITE HISTIDINE IN CHAIN B |
| Chain | Residue |
| B | HIS15 |
Functional Information from PROSITE/UniProt
| site_id | PS00369 |
| Number of Residues | 8 |
| Details | PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GIHARPAT |
| Chain | Residue | Details |
| A | GLY13-THR20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 172 |
| Details | Domain: {"description":"HPr","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Pros-phosphohistidine intermediate; alternate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1549615","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17218307","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Tele-phosphohistidine; alternate","evidences":[{"source":"PubMed","id":"1549615","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by HPrK/P","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17218307","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
