1SOJ
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
C | 0007165 | biological_process | signal transduction |
C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
D | 0007165 | biological_process | signal transduction |
D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
E | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
E | 0007165 | biological_process | signal transduction |
E | 0008081 | molecular_function | phosphoric diester hydrolase activity |
F | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
F | 0007165 | biological_process | signal transduction |
F | 0008081 | molecular_function | phosphoric diester hydrolase activity |
G | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
G | 0007165 | biological_process | signal transduction |
G | 0008081 | molecular_function | phosphoric diester hydrolase activity |
H | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
H | 0007165 | biological_process | signal transduction |
H | 0008081 | molecular_function | phosphoric diester hydrolase activity |
I | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
I | 0007165 | biological_process | signal transduction |
I | 0008081 | molecular_function | phosphoric diester hydrolase activity |
J | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
J | 0007165 | biological_process | signal transduction |
J | 0008081 | molecular_function | phosphoric diester hydrolase activity |
K | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
K | 0007165 | biological_process | signal transduction |
K | 0008081 | molecular_function | phosphoric diester hydrolase activity |
L | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
L | 0007165 | biological_process | signal transduction |
L | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 2123 |
Chain | Residue |
A | HOH11 |
A | HOH16 |
A | HIS741 |
A | HIS821 |
A | ASP822 |
A | ASP937 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 2124 |
Chain | Residue |
A | HOH14 |
A | HOH15 |
A | ASP822 |
A | HOH11 |
A | HOH12 |
A | HOH13 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 2125 |
Chain | Residue |
B | HOH21 |
B | HOH25 |
B | HIS741 |
B | HIS821 |
B | ASP822 |
B | ASP937 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 2126 |
Chain | Residue |
B | HOH21 |
B | HOH22 |
B | HOH23 |
B | HOH24 |
B | HOH26 |
B | ASP822 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 2127 |
Chain | Residue |
C | HOH31 |
C | HOH36 |
C | HIS741 |
C | HIS821 |
C | ASP822 |
C | ASP937 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 2128 |
Chain | Residue |
C | HOH31 |
C | HOH32 |
C | HOH33 |
C | HOH34 |
C | HOH35 |
C | ASP822 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 2129 |
Chain | Residue |
D | HOH41 |
D | HOH45 |
D | HIS741 |
D | HIS821 |
D | ASP822 |
D | ASP937 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 2130 |
Chain | Residue |
D | HOH41 |
D | HOH42 |
D | HOH43 |
D | HOH44 |
D | HOH46 |
D | ASP822 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG E 2131 |
Chain | Residue |
E | HOH51 |
E | HOH56 |
E | HIS741 |
E | HIS821 |
E | ASP822 |
E | ASP937 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG E 2132 |
Chain | Residue |
E | HOH51 |
E | HOH52 |
E | HOH53 |
E | HOH54 |
E | HOH55 |
E | ASP822 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG F 2133 |
Chain | Residue |
F | HOH61 |
F | HOH65 |
F | HIS741 |
F | HIS821 |
F | ASP822 |
F | ASP937 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG F 2134 |
Chain | Residue |
F | HOH61 |
F | HOH62 |
F | HOH63 |
F | HOH64 |
F | HOH66 |
F | ASP822 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG G 2135 |
Chain | Residue |
G | HOH71 |
G | HOH76 |
G | HIS741 |
G | HIS821 |
G | ASP822 |
G | ASP937 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG G 2136 |
Chain | Residue |
G | HOH71 |
G | HOH72 |
G | HOH73 |
G | HOH74 |
G | HOH75 |
G | ASP822 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG H 2137 |
Chain | Residue |
H | HOH81 |
H | HOH85 |
H | HIS741 |
H | HIS821 |
H | ASP822 |
H | ASP937 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG H 2138 |
Chain | Residue |
H | HOH81 |
H | HOH82 |
H | HOH83 |
H | HOH84 |
H | HOH86 |
H | ASP822 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG I 2139 |
Chain | Residue |
I | HIS821 |
I | ASP822 |
I | ASP937 |
I | HOH91 |
I | HOH96 |
I | HIS741 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG I 2140 |
Chain | Residue |
I | HOH91 |
I | HOH92 |
I | HOH93 |
I | HOH94 |
I | HOH95 |
I | ASP822 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG J 2141 |
Chain | Residue |
J | HOH101 |
J | HOH105 |
J | HIS741 |
J | HIS821 |
J | ASP822 |
J | ASP937 |
site_id | CC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG J 2142 |
Chain | Residue |
J | HOH101 |
J | HOH102 |
J | HOH103 |
J | HOH104 |
J | HOH106 |
J | ASP822 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG K 2143 |
Chain | Residue |
K | HOH111 |
K | HOH116 |
K | HIS741 |
K | HIS821 |
K | ASP822 |
K | ASP937 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG K 2144 |
Chain | Residue |
K | HOH111 |
K | HOH112 |
K | HOH113 |
K | HOH114 |
K | HOH115 |
K | ASP822 |
site_id | CC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG L 2145 |
Chain | Residue |
L | HOH121 |
L | HOH125 |
L | HIS741 |
L | HIS821 |
L | ASP822 |
L | ASP937 |
L | MG2146 |
site_id | CC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG L 2146 |
Chain | Residue |
L | HOH121 |
L | HOH122 |
L | HOH123 |
L | HOH124 |
L | HOH126 |
L | ASP822 |
L | MG2145 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM A 2111 |
Chain | Residue |
A | TYR736 |
A | ILE938 |
A | ILE955 |
A | GLN988 |
A | PHE991 |
A | HOH1125 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM B 2112 |
Chain | Residue |
B | TYR736 |
B | ILE938 |
B | ILE955 |
B | GLN988 |
B | PHE991 |
B | HOH1130 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM C 2113 |
Chain | Residue |
C | TYR736 |
C | ILE938 |
C | PRO941 |
C | GLN988 |
C | PHE991 |
C | HOH1225 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM D 2114 |
Chain | Residue |
D | TYR736 |
D | PRO941 |
D | ILE955 |
D | GLN988 |
D | PHE991 |
D | HOH1230 |
site_id | DC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM E 2115 |
Chain | Residue |
E | TYR736 |
E | ILE938 |
E | PRO941 |
E | GLN988 |
E | PHE991 |
E | HOH1325 |
site_id | DC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM F 2116 |
Chain | Residue |
F | TYR736 |
F | ILE938 |
F | ILE955 |
F | GLN988 |
F | PHE991 |
F | HOH1330 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IBM G 2117 |
Chain | Residue |
G | ILE938 |
G | ILE955 |
G | GLN988 |
G | PHE991 |
G | HOH1425 |
site_id | DC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM H 2118 |
Chain | Residue |
H | TYR736 |
H | ILE938 |
H | ILE955 |
H | GLN988 |
H | PHE991 |
H | HOH1430 |
site_id | DC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE IBM I 2119 |
Chain | Residue |
I | TYR736 |
I | ILE938 |
I | PRO941 |
I | ILE955 |
I | GLN988 |
I | PHE991 |
I | HOH1525 |
site_id | DC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE IBM J 2120 |
Chain | Residue |
J | TYR736 |
J | ILE938 |
J | PRO941 |
J | ILE955 |
J | GLN988 |
J | PHE991 |
J | HOH1530 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IBM K 2121 |
Chain | Residue |
K | TYR736 |
K | ILE938 |
K | GLN988 |
K | PHE991 |
K | HOH1625 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IBM L 2122 |
Chain | Residue |
L | TYR736 |
L | ILE938 |
L | ILE955 |
L | GLN988 |
L | PHE991 |
L | HOH1630 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYdHpGrtNaF |
Chain | Residue | Details |
A | HIS821-PHE832 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
Chain | Residue | Details |
A | HIS737 | |
B | HIS737 | |
C | HIS737 | |
D | HIS737 | |
E | HIS737 | |
F | HIS737 | |
G | HIS737 | |
H | HIS737 | |
I | HIS737 | |
J | HIS737 | |
K | HIS737 | |
L | HIS737 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q14432 |
Chain | Residue | Details |
A | HIS737 | |
A | GLN988 | |
B | HIS737 | |
B | GLN988 | |
C | HIS737 | |
C | GLN988 | |
D | HIS737 | |
D | GLN988 | |
E | HIS737 | |
E | GLN988 | |
F | HIS737 | |
F | GLN988 | |
G | HIS737 | |
G | GLN988 | |
H | HIS737 | |
H | GLN988 | |
I | HIS737 | |
I | GLN988 | |
J | HIS737 | |
J | GLN988 | |
K | HIS737 | |
K | GLN988 | |
L | HIS737 | |
L | GLN988 |
site_id | SWS_FT_FI3 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15147193, ECO:0007744|PDB:1SO2, ECO:0007744|PDB:1SOJ |
Chain | Residue | Details |
E | HIS741 | |
E | HIS821 | |
E | ASP937 | |
F | HIS741 | |
F | HIS821 | |
F | ASP937 | |
G | HIS741 | |
G | HIS821 | |
G | ASP937 | |
H | HIS741 | |
H | HIS821 | |
H | ASP937 | |
I | HIS741 | |
I | HIS821 | |
I | ASP937 | |
J | HIS741 | |
J | HIS821 | |
J | ASP937 | |
K | HIS741 | |
K | HIS821 | |
K | ASP937 | |
L | HIS741 | |
L | HIS821 | |
L | ASP937 | |
A | HIS741 | |
A | HIS821 | |
A | ASP937 | |
B | HIS741 | |
B | HIS821 | |
B | ASP937 | |
C | HIS741 | |
C | HIS821 | |
C | ASP937 | |
D | HIS741 | |
D | HIS821 | |
D | ASP937 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15147193, ECO:0007744|PDB:1SO2 |
Chain | Residue | Details |
A | ASP822 | |
B | ASP822 | |
C | ASP822 | |
D | ASP822 | |
E | ASP822 | |
F | ASP822 | |
G | ASP822 | |
H | ASP822 | |
I | ASP822 | |
J | ASP822 | |
K | ASP822 | |
L | ASP822 |