Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1SOJ

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity
E	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
E	0007165	biological_process	signal transduction
E	0008081	molecular_function	phosphoric diester hydrolase activity
F	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
F	0007165	biological_process	signal transduction
F	0008081	molecular_function	phosphoric diester hydrolase activity
G	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
G	0007165	biological_process	signal transduction
G	0008081	molecular_function	phosphoric diester hydrolase activity
H	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
H	0007165	biological_process	signal transduction
H	0008081	molecular_function	phosphoric diester hydrolase activity
I	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
I	0007165	biological_process	signal transduction
I	0008081	molecular_function	phosphoric diester hydrolase activity
J	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
J	0007165	biological_process	signal transduction
J	0008081	molecular_function	phosphoric diester hydrolase activity
K	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
K	0007165	biological_process	signal transduction
K	0008081	molecular_function	phosphoric diester hydrolase activity
L	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
L	0007165	biological_process	signal transduction
L	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2123

Chain	Residue
A	HOH11
A	HOH16
A	HIS741
A	HIS821
A	ASP822
A	ASP937

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2124

Chain	Residue
A	HOH14
A	HOH15
A	ASP822
A	HOH11
A	HOH12
A	HOH13

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2125

Chain	Residue
B	HOH21
B	HOH25
B	HIS741
B	HIS821
B	ASP822
B	ASP937

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2126

Chain	Residue
B	HOH21
B	HOH22
B	HOH23
B	HOH24
B	HOH26
B	ASP822

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 2127

Chain	Residue
C	HOH31
C	HOH36
C	HIS741
C	HIS821
C	ASP822
C	ASP937

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 2128

Chain	Residue
C	HOH31
C	HOH32
C	HOH33
C	HOH34
C	HOH35
C	ASP822

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 2129

Chain	Residue
D	HOH41
D	HOH45
D	HIS741
D	HIS821
D	ASP822
D	ASP937

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 2130

Chain	Residue
D	HOH41
D	HOH42
D	HOH43
D	HOH44
D	HOH46
D	ASP822

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 2131

Chain	Residue
E	HOH51
E	HOH56
E	HIS741
E	HIS821
E	ASP822
E	ASP937

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 2132

Chain	Residue
E	HOH51
E	HOH52
E	HOH53
E	HOH54
E	HOH55
E	ASP822

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 2133

Chain	Residue
F	HOH61
F	HOH65
F	HIS741
F	HIS821
F	ASP822
F	ASP937

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 2134

Chain	Residue
F	HOH61
F	HOH62
F	HOH63
F	HOH64
F	HOH66
F	ASP822

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 2135

Chain	Residue
G	HOH71
G	HOH76
G	HIS741
G	HIS821
G	ASP822
G	ASP937

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 2136

Chain	Residue
G	HOH71
G	HOH72
G	HOH73
G	HOH74
G	HOH75
G	ASP822

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 2137

Chain	Residue
H	HOH81
H	HOH85
H	HIS741
H	HIS821
H	ASP822
H	ASP937

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 2138

Chain	Residue
H	HOH81
H	HOH82
H	HOH83
H	HOH84
H	HOH86
H	ASP822

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG I 2139

Chain	Residue
I	HIS821
I	ASP822
I	ASP937
I	HOH91
I	HOH96
I	HIS741

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG I 2140

Chain	Residue
I	HOH91
I	HOH92
I	HOH93
I	HOH94
I	HOH95
I	ASP822

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 2141

Chain	Residue
J	HOH101
J	HOH105
J	HIS741
J	HIS821
J	ASP822
J	ASP937

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 2142

Chain	Residue
J	HOH101
J	HOH102
J	HOH103
J	HOH104
J	HOH106
J	ASP822

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG K 2143

Chain	Residue
K	HOH111
K	HOH116
K	HIS741
K	HIS821
K	ASP822
K	ASP937

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG K 2144

Chain	Residue
K	HOH111
K	HOH112
K	HOH113
K	HOH114
K	HOH115
K	ASP822

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG L 2145

Chain	Residue
L	HOH121
L	HOH125
L	HIS741
L	HIS821
L	ASP822
L	ASP937
L	MG2146

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG L 2146

Chain	Residue
L	HOH121
L	HOH122
L	HOH123
L	HOH124
L	HOH126
L	ASP822
L	MG2145

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM A 2111

Chain	Residue
A	TYR736
A	ILE938
A	ILE955
A	GLN988
A	PHE991
A	HOH1125

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM B 2112

Chain	Residue
B	TYR736
B	ILE938
B	ILE955
B	GLN988
B	PHE991
B	HOH1130

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM C 2113

Chain	Residue
C	TYR736
C	ILE938
C	PRO941
C	GLN988
C	PHE991
C	HOH1225

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM D 2114

Chain	Residue
D	TYR736
D	PRO941
D	ILE955
D	GLN988
D	PHE991
D	HOH1230

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM E 2115

Chain	Residue
E	TYR736
E	ILE938
E	PRO941
E	GLN988
E	PHE991
E	HOH1325

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM F 2116

Chain	Residue
F	TYR736
F	ILE938
F	ILE955
F	GLN988
F	PHE991
F	HOH1330

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IBM G 2117

Chain	Residue
G	ILE938
G	ILE955
G	GLN988
G	PHE991
G	HOH1425

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM H 2118

Chain	Residue
H	TYR736
H	ILE938
H	ILE955
H	GLN988
H	PHE991
H	HOH1430

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IBM I 2119

Chain	Residue
I	TYR736
I	ILE938
I	PRO941
I	ILE955
I	GLN988
I	PHE991
I	HOH1525

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IBM J 2120

Chain	Residue
J	TYR736
J	ILE938
J	PRO941
J	ILE955
J	GLN988
J	PHE991
J	HOH1530

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IBM K 2121

Chain	Residue
K	TYR736
K	ILE938
K	GLN988
K	PHE991
K	HOH1625

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IBM L 2122

Chain	Residue
L	TYR736
L	ILE938
L	ILE955
L	GLN988
L	PHE991
L	HOH1630

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYdHpGrtNaF

Chain	Residue	Details
A	HIS821-PHE832

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q14432","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15147193","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SOJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15147193","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)