Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1SMK

Mature and translocatable forms of glyoxysomal malate dehydrogenase have different activities and stabilities but similar crystal structures

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006097	biological_process	glyoxylate cycle
A	0006099	biological_process	tricarboxylic acid cycle
A	0006108	biological_process	malate metabolic process
A	0009507	cellular_component	chloroplast
A	0009514	cellular_component	glyoxysome
A	0016491	molecular_function	oxidoreductase activity
A	0016615	molecular_function	malate dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0006097	biological_process	glyoxylate cycle
B	0006099	biological_process	tricarboxylic acid cycle
B	0006108	biological_process	malate metabolic process
B	0009507	cellular_component	chloroplast
B	0009514	cellular_component	glyoxysome
B	0016491	molecular_function	oxidoreductase activity
B	0016615	molecular_function	malate dehydrogenase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
C	0003824	molecular_function	catalytic activity
C	0005737	cellular_component	cytoplasm
C	0006097	biological_process	glyoxylate cycle
C	0006099	biological_process	tricarboxylic acid cycle
C	0006108	biological_process	malate metabolic process
C	0009507	cellular_component	chloroplast
C	0009514	cellular_component	glyoxysome
C	0016491	molecular_function	oxidoreductase activity
C	0016615	molecular_function	malate dehydrogenase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
D	0003824	molecular_function	catalytic activity
D	0005737	cellular_component	cytoplasm
D	0006097	biological_process	glyoxylate cycle
D	0006099	biological_process	tricarboxylic acid cycle
D	0006108	biological_process	malate metabolic process
D	0009507	cellular_component	chloroplast
D	0009514	cellular_component	glyoxysome
D	0016491	molecular_function	oxidoreductase activity
D	0016615	molecular_function	malate dehydrogenase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
E	0003824	molecular_function	catalytic activity
E	0005737	cellular_component	cytoplasm
E	0006097	biological_process	glyoxylate cycle
E	0006099	biological_process	tricarboxylic acid cycle
E	0006108	biological_process	malate metabolic process
E	0009507	cellular_component	chloroplast
E	0009514	cellular_component	glyoxysome
E	0016491	molecular_function	oxidoreductase activity
E	0016615	molecular_function	malate dehydrogenase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
E	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
F	0003824	molecular_function	catalytic activity
F	0005737	cellular_component	cytoplasm
F	0006097	biological_process	glyoxylate cycle
F	0006099	biological_process	tricarboxylic acid cycle
F	0006108	biological_process	malate metabolic process
F	0009507	cellular_component	chloroplast
F	0009514	cellular_component	glyoxysome
F	0016491	molecular_function	oxidoreductase activity
F	0016615	molecular_function	malate dehydrogenase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
F	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
G	0003824	molecular_function	catalytic activity
G	0005737	cellular_component	cytoplasm
G	0006097	biological_process	glyoxylate cycle
G	0006099	biological_process	tricarboxylic acid cycle
G	0006108	biological_process	malate metabolic process
G	0009507	cellular_component	chloroplast
G	0009514	cellular_component	glyoxysome
G	0016491	molecular_function	oxidoreductase activity
G	0016615	molecular_function	malate dehydrogenase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
G	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
H	0003824	molecular_function	catalytic activity
H	0005737	cellular_component	cytoplasm
H	0006097	biological_process	glyoxylate cycle
H	0006099	biological_process	tricarboxylic acid cycle
H	0006108	biological_process	malate metabolic process
H	0009507	cellular_component	chloroplast
H	0009514	cellular_component	glyoxysome
H	0016491	molecular_function	oxidoreductase activity
H	0016615	molecular_function	malate dehydrogenase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
H	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CIT C 1313

Chain	Residue
C	ILE56
C	ALA267
C	ARG124
C	ARG130
C	ASN162
C	ARG196
C	HIS220
C	GLY254
C	VAL258
C	SER266

Functional Information from PROSITE/UniProt

site_id	PS00068
Number of Residues	13
Details	MDH Malate dehydrogenase active site signature. VTMLDvvRAntfV

Chain	Residue	Details
A	VAL189-VAL201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	88
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
A	ASP193
A	HIS220

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
B	ASP193
B	HIS220
B	ARG196

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
C	ASP193
C	HIS220
C	ARG196

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
D	ASP193
D	HIS220
D	ARG196

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
E	ASP193
E	HIS220
E	ARG196

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
F	ASP193
F	HIS220
F	ARG196

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
G	ASP193
G	HIS220
G	ARG196

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
H	ASP193
H	HIS220
H	ARG196

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
B	ASP193
B	HIS220

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
C	ASP193
C	HIS220

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
D	ASP193
D	HIS220

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
E	ASP193
E	HIS220

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
F	ASP193
F	HIS220

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
G	ASP193
G	HIS220

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
H	ASP193
H	HIS220

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1emd

Chain	Residue	Details
A	ASP193
A	HIS220
A	ARG196

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)