Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1SK1

ARSENATE REDUCTASE R60K MUTANT +0.4M ARSENATE FROM E. COLI

Functional Information from GO Data
ChainGOidnamespacecontents
A0008794molecular_functionarsenate reductase (glutaredoxin) activity
A0016491molecular_functionoxidoreductase activity
A0046685biological_processresponse to arsenic-containing substance
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 201
ChainResidue
ACSR12
AGLY13
ATHR14
AASN62
AGLU67
AHOH1033
AHOH1076
AHOH1099
AHOH1303

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
AASN93
AARG107
AHOH1102
AHOH1116
AHOH1180
AHOH1235

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
ATHR14
AASN17
APRO108
ASER109
ALYS126
AHOH1033
AHOH1052
AHOH1123
AHOH1167
AHOH1170
AHOH1176

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CS A 401
ChainResidue
ALEU113
ALEU113
AASP114
AASP114
ALEU116
ALEU116

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CS A 402
ChainResidue
AASP128

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CS A 403
ChainResidue
APRO38
ASER40
AGLU43

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile; cysteine thioarsenate intermediate => ECO:0000255|PROSITE-ProRule:PRU01282, ECO:0000269|PubMed:11709171, ECO:0000269|PubMed:15295115, ECO:0000269|PubMed:7577935
ChainResidueDetails
ACSR12

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Important for activity. Lowers pKa of the active site Cys => ECO:0000269|PubMed:8969183
ChainResidueDetails
AHIS8

site_idSWS_FT_FI3
Number of Residues3
DetailsSITE: Important for activity. Involved in arsenate binding and transition-state stabilization => ECO:0000269|PubMed:11709171, ECO:0000269|PubMed:14592722, ECO:0000269|PubMed:15295115
ChainResidueDetails
ALYS60
AARG94
AARG107

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon