1SIO

Structure of Kumamolisin-As complexed with a covalently-bound inhibitor, AcIPF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	GLU19
A	GLY20
A	ARG290
A	HOH1583
A	HOH1808
A	HOH1853
A	HOH2353

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 601

Chain	Residue
A	GLY334
A	GLY336
A	ASP338
A	HOH1501
A	ASP316
A	ILE317

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	GLU133
B	ASP134
B	TYR176
B	HIS177
B	VAL178
B	ARG223
B	HOH1721
B	HOH2056
B	HOH2196

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 602

Chain	Residue
B	ASP316
B	ILE317
B	GLY334
B	GLY336
B	ASP338
B	HOH2501

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 503

Chain	Residue
C	LYS121
C	ARG327
C	GLN329
C	HOH1862
C	HOH1995
C	HOH2120

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 603

Chain	Residue
C	ASP316
C	ILE317
C	GLY334
C	GLY336
C	ASP338
C	HOH3501

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR

Chain	Residue
A	GLU78
A	ASN102
A	SER128
A	TRP129
A	GLY130
A	ASP164
A	ASP179
A	GLY276
A	THR277
A	SER278
D	HOH1824
D	HOH1972
D	HOH2402

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR

Chain	Residue
B	GLU78
B	ASN102
B	SER128
B	TRP129
B	GLY130
B	ASP164
B	ASP179
B	GLY276
B	THR277
B	SER278
B	HOH1751
E	HOH1940

---

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR

Chain	Residue
C	GLU78
C	ASN102
C	SER128
C	TRP129
C	GLY130
C	ASP164
C	ASP179
C	GLY276
C	THR277
C	SER278
F	HOH2377
F	HOH2385

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"15014068","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16704427","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15014068","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16704427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SIU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SN7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZVK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1nlu

Chain	Residue	Details
A	SER278
A	ASP164
A	ASP82
A	GLU78

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1nlu

Chain	Residue	Details
B	SER278
B	ASP164
B	ASP82
B	GLU78

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1nlu

Chain	Residue	Details
C	SER278
C	ASP164
C	ASP82
C	GLU78

---